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Challenges of antibacterial discovery revisited

Annals of the New York Academy of Sciences, 2010-12, Vol.1213 (1), p.5-19

2010

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Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics

Antimicrobial agents and chemotherapy, 2017-09, Vol.61 (9)

2017

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Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

Frontiers in immunology, 2021-07, Vol.12, p.705360-705360

2021

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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.289-298

2015

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Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Antimicrobial Agents and Chemotherapy, 2006-11, Vol.50 (11), p.3882-3885

2006

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In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains

Antimicrobial agents and chemotherapy, 2016-02, Vol.60 (2), p.729-734

2016

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In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

Journal of antimicrobial chemotherapy, 2016-03, Vol.71 (3), p.670-677

2016

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Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)

2019

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Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

Antimicrobial Agents and Chemotherapy, 2003-06, Vol.47 (6), p.1784-1789

2003

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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Antimicrobial Agents and Chemotherapy, 2002-06, Vol.46 (6), p.1880-1886

2002

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1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models

Open forum infectious diseases, 2019-10, Vol.6 (Supplement_2), p.S569-S569

2019

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Journal of visualized experiments, 2017-01 (119)

2017

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Journal of visualized experiments, 2017-01 (119)

2017

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Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7483-7488

2011

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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7489-7495

2011

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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1282-1292

2000

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248S-649266, a Novel Siderophore Cephalosporin: Efficacy against Klebsiella pneumoniae producing NDM-1 or KPC in rat lung infection model with recreated humanized exposure profile of 2 gram dose with 1 hour and 3 hours infusion

Open forum infectious diseases, 2014-12, Vol.1 (suppl_1), p.S106-S107

2014

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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3937-3941

2004

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In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

Journal of antimicrobial chemotherapy, 2000-04, Vol.45 (suppl-3), p.13-13

2000

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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.665-668

2003

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In vitro antibacterial activity of gemifloxacin and comparator compounds against common respiratory pathogens

Journal of antimicrobial chemotherapy, 2000-04, Vol.45 (suppl-3), p.23-23

2000

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Information from your family doctor: Questions and answers about TB

American family physician, 2000-05, Vol.61 (9), p.2681

2000

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Identification and management of tuberculosis

American family physician, 2000-05, Vol.61 (9), p.2667-2678

2000

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Low- versus high-pressure irrigation techniques in Staphylococcus aureus-inoculated wounds

The American journal of emergency medicine, 1999-03, Vol.17 (2), p.121-124

1999

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A survey of β-lactamase-producing Haemophilus influenzae an evaluation of 5750 isolates

Diagnostic microbiology and infectious disease, 1995-04, Vol.21 (4), p.223-225

1995

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Challenges of antibacterial discovery revisited

Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains

In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model

Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

248S-649266, a Novel Siderophore Cephalosporin: Efficacy against Klebsiella pneumoniae producing NDM-1 or KPC in rat lung infection model with recreated humanized exposure profile of 2 gram dose with 1 hour and 3 hours infusion

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

In vitro antibacterial activity of gemifloxacin and comparator compounds against common respiratory pathogens

Information from your family doctor: Questions and answers about TB

Identification and management of tuberculosis

Low- versus high-pressure irrigation techniques in Staphylococcus aureus-inoculated wounds

A survey of β-lactamase-producing Haemophilus influenzae an evaluation of 5750 isolates

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