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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Nucleic acids research, 2019-07, Vol.47 (12), p.6029

2019

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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Molecular metabolism (Germany), 2019-04, Vol.22 (April), p.49-61

2019

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Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

Cell reports (Cambridge), 2014-05, Vol.7 (3), p.774-784

2014

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Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

ESC Heart Failure, 2021-02, Vol.8 (1), p.652-661

2021

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Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors

Cell death & disease, 2024-02, Vol.15 (2), p.140-140, Article 140

2024

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Seagrass rehabilitation off metropolitan Adelaide: a case study of loss, action, failure and success

Ecological management & restoration, 2014-09, Vol.15 (3), p.168-179

2014

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Lineage 2 west nile virus as cause of fatal neurologic disease in horses, South Africa

Emerging infectious diseases, 2009-06, Vol.15 (6), p.877-884

2009

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Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis

The American journal of pathology, 2019-10, Vol.189 (10), p.2077-2089

2019

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1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency

Diabetes (New York, N.Y.), 2023-06, Vol.72 (Supplement_1), p.1

2023

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Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice

Science translational medicine, 2021-07, Vol.13 (604)

2021

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The gap remains: NHMRC research funding for suicide and self‐harm, 2000–2014

Medical journal of Australia, 2015-06, Vol.202 (10), p.525-526

2015

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224-OR: Antisense Oligonucleotide–Mediated Restriction of Mitochondrial Pyruvate Metabolism Limits DNL in High-Fat Fed C57BL6/J Mice

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Characterization of target mRNA reduction through in situ RNA hybridization in multiple organ systems following systemic antisense treatment in animals

Nucleic acid therapeutics, 2013-12, Vol.23 (6), p.369

2013

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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Nucleic acids research, 2019-07, Vol.47 (12), p.6045

2019

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Undergraduate Therapeutic Radiography: Perceptions on Curricula Delivery and Preparedness for Practice Using an Appreciative Inquiry Approach

Murray, Sue

2020

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ProQuest

Inhibition of Transcriptional Regulator Taz (Wwtr1) by Antisense Oligonucleotide (ASO) Treatment Improves Obesity and Hepatic Steatosis in a Mouse Model of NASH

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition

Proceedings of the National Academy of Sciences - PNAS, 2023-12, Vol.120 (52), p.e2312666120

2023

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2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets

Diabetes (New York, N.Y.), 2019-06, Vol.68 (Supplement_1)

2019

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Sub‐organ Fractionation of Hepatic Cells after Antisense Oligonucleotide Treatment in Mice

The FASEB journal, 2018-04, Vol.32 (S1), p.760.11-760.11

2018

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2092-P: Invalidation of GSK3B in Pancreatic Beta Cell as a Therapeutic Target for T2D

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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2066-P: Dyrk1a Antisense Oligonucleotides Conjugated to GLP-1R Agonist Promote Pancreatic Beta-Cell Proliferation

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry

Nucleic acids research, 2012-07, Vol.40 (13), p.6135

2012

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Targeting Ketohexokinase (KHK) with a Novel Antisense Oligonucleotide (ASO) Decreases De Novo Lipogenesis and Improves Insulin-Mediated Whole Body Glucose Metabolism

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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LipidSIM: Inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, Markov modeling framework

Metabolic engineering, 2024-03, Vol.82, p.110-122

2024

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Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis

The American journal of pathology, 2019-10, Vol.189 (10), p.2077-2089

2019

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors

Seagrass rehabilitation off metropolitan Adelaide: a case study of loss, action, failure and success

Lineage 2 west nile virus as cause of fatal neurologic disease in horses, South Africa

Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis

1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency

Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice

The gap remains: NHMRC research funding for suicide and self‐harm, 2000–2014

224-OR: Antisense Oligonucleotide–Mediated Restriction of Mitochondrial Pyruvate Metabolism Limits DNL in High-Fat Fed C57BL6/J Mice

Characterization of target mRNA reduction through in situ RNA hybridization in multiple organ systems following systemic antisense treatment in animals

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Undergraduate Therapeutic Radiography: Perceptions on Curricula Delivery and Preparedness for Practice Using an Appreciative Inquiry Approach

Inhibition of Transcriptional Regulator Taz (Wwtr1) by Antisense Oligonucleotide (ASO) Treatment Improves Obesity and Hepatic Steatosis in a Mouse Model of NASH

Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition

2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets

Sub‐organ Fractionation of Hepatic Cells after Antisense Oligonucleotide Treatment in Mice

2092-P: Invalidation of GSK3B in Pancreatic Beta Cell as a Therapeutic Target for T2D

2066-P: Dyrk1a Antisense Oligonucleotides Conjugated to GLP-1R Agonist Promote Pancreatic Beta-Cell Proliferation

TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry

Targeting Ketohexokinase (KHK) with a Novel Antisense Oligonucleotide (ASO) Decreases De Novo Lipogenesis and Improves Insulin-Mediated Whole Body Glucose Metabolism

LipidSIM: Inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, Markov modeling framework

Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis

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