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Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

Pain (Amsterdam), 2018-09, Vol.159 (9), p.1752-1763

2018

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Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Nature communications, 2016-02, Vol.7 (1), p.10555-10555, Article 10555

2016

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Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.13967-13987

2022

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Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders

European journal of medicinal chemistry, 2022-03, Vol.231, p.114162-114162, Article 114162

2022

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Structural insights into the human P2X1 receptor and ligand interactions

Nature communications, 2024-09, Vol.15 (1), p.8418-14, Article 8418

2024

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CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy

Diabetes (New York, N.Y.), 2017-02, Vol.66 (2), p.483-493

2017

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New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors

European journal of medicinal chemistry, 2016-01, Vol.107, p.204-218

2016

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Exploratory study of oxatomide derivatives with high P2X 7 receptor inhibitory activity

Bioorganic & medicinal chemistry letters, 2022-12, Vol.77, p.129035

2022

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The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

Science translational medicine, 2015-05, Vol.7 (287), p.287ra72

2015

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Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System

Journal of cellular physiology, 2016-08, Vol.231 (8), p.1656-1670

2016

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P2X receptor agonist enhances tumor-specific CTL responses through CD70+ DC-mediated Th17 induction

International immunology, 2021-01, Vol.33 (1), p.49-55

2021

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PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells

European journal of pharmacology, 2021-05, Vol.899, p.174041-174041, Article 174041

2021

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The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis

The Journal of immunology (1950), 2013-05, Vol.190 (10), p.5187-5195

2013

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Caveolin-1 regulates P2X7 receptor signaling in osteoblasts

American Journal of Physiology: Cell Physiology, 2015-01, Vol.308 (1), p.C41-C50

2015

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Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization

Journal of the American Society of Nephrology, 2016-03, Vol.27 (3), p.848-862

2016

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Silica nanoparticles activate purinergic signaling via P2X7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines

Toxicology in vitro, 2016-09, Vol.35, p.202-211

2016

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A potential role for P2X7R in allergic airway inflammation in mice and humans

American journal of respiratory cell and molecular biology, 2011-04, Vol.44 (4), p.456-464

2011

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Block of Purinergic P2X7R Inhibits Tumor Growth in a C6 Glioma Brain Tumor Animal Model

Journal of neuropathology and experimental neurology, 2011-01, Vol.70 (1), p.13-22

2011

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The ATP-gated P2X 1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice

Scientific reports, 2019-12, Vol.9 (1), p.5159

2019

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P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway

The international journal of biochemistry & cell biology, 2013-06, Vol.45 (6), p.1109-1120

2013

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Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

Scientific reports, 2016-01, Vol.6 (1), p.19108-19108, Article 19108

2016

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18 F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

Journal of Nuclear Medicine, 2019-05, Vol.60 (5), p.683-690

2019

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The role of P2X7 receptors in tissue fibrosis: a brief review

Purinergic signalling, 2015-12, Vol.11 (4), p.435-440

2015

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Structure–activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists

European journal of medicinal chemistry, 2015-12, Vol.106, p.180-193

2015

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Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

Molecular pain, 2014-06, Vol.10 (1), p.37-37

2014

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Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists

Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders

Structural insights into the human P2X1 receptor and ligand interactions

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy

New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors

Exploratory study of oxatomide derivatives with high P2X 7 receptor inhibitory activity

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System

P2X receptor agonist enhances tumor-specific CTL responses through CD70+ DC-mediated Th17 induction

PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells

The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis

Caveolin-1 regulates P2X7 receptor signaling in osteoblasts

Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization

Silica nanoparticles activate purinergic signaling via P2X7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines

A potential role for P2X7R in allergic airway inflammation in mice and humans

Block of Purinergic P2X7R Inhibits Tumor Growth in a C6 Glioma Brain Tumor Animal Model

The ATP-gated P2X 1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice

P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway

Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

18 F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

The role of P2X7 receptors in tissue fibrosis: a brief review

Structure–activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists

Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

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