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Brief history of anti‐seizure drug development

Epilepsia open, 2018-12, Vol.3 (Suppl Suppl 2), p.114-119

2018

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Mechanisms of Action of Antiepileptic Drugs

International Review of Neurobiology, 2007, Vol.81 (2), p.85-110

2007

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Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, modifies acute seizure burden and chronic epilepsy-related behavioral deficits following Theiler's virus infection in mice

Neuropharmacology, 2023-01, Vol.222, p.109310-109310, Article 109310

2023

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Models for Epilepsy and Epileptogenesis: Report from the NIH Workshop, Bethesda, Maryland

Epilepsia (Copenhagen), 2002-11, Vol.43 (11), p.1410-1420

2002

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Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

Epilepsia (Copenhagen), 2017-02, Vol.58 (2), p.181-221

2017

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Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

Epilepsia (Copenhagen), 2017-03, Vol.58 (3), p.484-493

2017

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NAX 810-2, A Novel Galanin-Based Therapy for Epilepsy

Neuropeptides (Edinburgh), 2017-10, Vol.65, p.150-150

2017

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Animal models for evaluating antiepileptogenesis

Epilepsia (Copenhagen), 2010-12, Vol.51 (s5), p.87-87

White, H. Steve

2010

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Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity

The Journal of pharmacology and experimental therapeutics, 2007-02, Vol.320 (2), p.828-836

2007

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Efficacy of mGlu 2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

Epilepsia (Copenhagen), 2017-03, Vol.58 (3), p.484-493

2017

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Anticonvulsant effects of a galanin receptor 3 (galr3) antagonist SNAP 37889 in mouse models of seizures

Neuropeptides (Edinburgh), 2017-10, Vol.65, p.139-139

2017

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Topiramate Modulates GABA‐Evoked Currents in Murine Cortical Neurons by a Nonbenzodiazepine Mechanism

Epilepsia (Copenhagen), 2000-01, Vol.41 (s1), p.17-20

2000

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New GABATargeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System

CNS drugs, 2023-09, Vol.37 (9), p.755-779

2023

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High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures

The Lancet (British edition), 2014-02, Vol.383, p.S105-S105

2014

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Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred versus inbred mice

Epilepsia (Copenhagen), 2020-08, Vol.61 (9), p.2022-2034

2020

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Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug

Neuropharmacology, 2006-09, Vol.51 (4), p.933-946

2006

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Recurrent Epileptiform Discharges in the Medial Entorhinal Cortex of Kainate-Treated Rats are Differentially Sensitive to Anti-Seizure Drugs

Epilepsia (Copenhagen), 2018-10, Vol.59 (11), p.2035-2048

2018

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Neuroinflammation in epileptogenesis: insights and translational perspectives from new models of epilepsies

Epilepsia (Copenhagen), 2017-07, Vol.58 (Suppl 3), p.39-47

2017

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Pre-Clinical Evaluation of Intravenous NAX 810-2, a Novel GalR2-Preferring Analog, for Anticonvulsant Efficacy and Pharmacokinetics

Epilepsia (Copenhagen), 2017-01, Vol.58 (2), p.239-246

2017

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Topiramate modulation of β1- and β3-homomeric GABAA receptors

Pharmacological research, 2011-07, Vol.64 (1), p.44-52

2011

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Subunit selectivity of topiramate modulation of heteromeric GABAA receptors

Neuropharmacology, 2006-06, Vol.50 (7), p.845-857

2006

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Neuroimaging Markers of Epileptogenesis

Epilepsy currents, 2003-03, Vol.3 (2), p.64-65

White, H. Steve

2003

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Neuroimaging Markers of Epileptogenesis

Epilepsy currents, 2003-03, Vol.3 (2), p.64-65

White, H. Steve

2003

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Deconstructing Tolerance with Clobazam: Post Hoc Analyses from an Open-Label Extension Study (S14.002)

Neurology, 2016-04, Vol.86 (16_supplement)

2016

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Antiseizure drugs differentially modulate theta‐burst induced long‐term potentiation in C 57 BL /6 mice

Epilepsia (Copenhagen), 2014-02, Vol.55 (2), p.214-223

2014

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Brief history of anti‐seizure drug development

Mechanisms of Action of Antiepileptic Drugs

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, modifies acute seizure burden and chronic epilepsy-related behavioral deficits following Theiler's virus infection in mice

Models for Epilepsy and Epileptogenesis: Report from the NIH Workshop, Bethesda, Maryland

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

NAX 810-2, A Novel Galanin-Based Therapy for Epilepsy

Animal models for evaluating antiepileptogenesis

Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity

Efficacy of mGlu 2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

Anticonvulsant effects of a galanin receptor 3 (galr3) antagonist SNAP 37889 in mouse models of seizures

Topiramate Modulates GABA‐Evoked Currents in Murine Cortical Neurons by a Nonbenzodiazepine Mechanism

New GABATargeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System

High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred versus inbred mice

Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug

Recurrent Epileptiform Discharges in the Medial Entorhinal Cortex of Kainate-Treated Rats are Differentially Sensitive to Anti-Seizure Drugs

Neuroinflammation in epileptogenesis: insights and translational perspectives from new models of epilepsies

Pre-Clinical Evaluation of Intravenous NAX 810-2, a Novel GalR2-Preferring Analog, for Anticonvulsant Efficacy and Pharmacokinetics

Topiramate modulation of β1- and β3-homomeric GABAA receptors

Subunit selectivity of topiramate modulation of heteromeric GABAA receptors

Neuroimaging Markers of Epileptogenesis

Neuroimaging Markers of Epileptogenesis

Deconstructing Tolerance with Clobazam: Post Hoc Analyses from an Open-Label Extension Study (S14.002)

Antiseizure drugs differentially modulate theta‐burst induced long‐term potentiation in C 57 BL /6 mice

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