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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

Neurochemical research, 2003-04, Vol.28 (3-4), p.437-442

2003

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Muscarinic mechanisms in psychotic disorders

Handbook of experimental pharmacology, 2012 (213), p.233

2012

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Case history: the discovery of fluoxetine hydrochloride (Prozac)

Nature reviews. Drug discovery, 2005-09, Vol.4 (9), p.764-774

2005

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Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder

Journal of experimental pharmacology, 2024, Vol.16, p.13-24

2024

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Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.14096-14101

2001

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

The FASEB journal, 2004-09, Vol.18 (12), p.1410-1412

2004

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Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine

The Journal of pharmacology and experimental therapeutics, 2005-12, Vol.315 (3), p.1265

2005

Volltextzugriff (PDF)

Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication

Life Sciences, 1995, Vol.57 (5), p.411-441

1995

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Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

Schizophrenia research, 2000-05, Vol.42 (3), p.249-259

2000

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Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum

Psychopharmacologia, 1998-03, Vol.136 (2), p.153-161

1998

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1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1999-2006

1999

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Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro

Schizophrenia research, 1999-05, Vol.37 (1), p.107-122

1999

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Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice

Life sciences (1973), 2001-04, Vol.68 (22-23), p.2457-2466

2001

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Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic receptors in vivo in rats

Psychopharmacology, 1996-03, Vol.124 (1-2), p.87-94

1996

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Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors

Biochemical pharmacology, 1983-04, Vol.32 (7), p.1287-1293

1983

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Biopharmaceutical characterization, metabolism, and brain penetration of the triple reuptake inhibitor amitifadine

Drug metabolism letters, 2013-03, Vol.7 (1), p.23

2013

Volltextzugriff (PDF)

Functionally selective M1 muscarinic agonists. 3. Side chain and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3469-3481

1995

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O3-06-06 Normalization of impaired hippocampal acetylcholine efflux following anti-Aβ antibody administration

Neurobiology of aging, 2004-07, Vol.25, p.S65-S65

2004

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related central nervous system pathologies

The FASEB journal, 2004-09, Vol.18 (12), p.1410-1412

2004

Volltextzugriff (PDF)

M sub(4) muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

The FASEB journal, 2004-09, Vol.18 (12), p.1410-1412

2004

Volltextzugriff (PDF)

Arachidonic Acid Release in Cell Lines Transfected with Muscarinic Receptors: A Simple Functional Assay to Determine Response of Agonists

Cellular signalling, 1999-06, Vol.11 (6), p.405-413

1999

Volltextzugriff (PDF)

Use of M^sub 1^-M^sub 5^ muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

Neurochemical research, 2003-04, Vol.28 (3/4), p.437

2003

Volltextzugriff (PDF)

Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype?

Progress in drug research, 2002, Vol.58, p.169

2002

Volltextzugriff (PDF)

PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man

Dementia (Basel, Switzerland), 1996, Vol.7 (4), p.187

1996

Volltextzugriff (PDF)

Muscarinic mechanisms of antipsychotic atypicality: Mechanism of atypicality of antipsychotic drugs

Progress in neuro-psychopharmacology & biological psychiatry, 2003, Vol.27 (7), p.1125-1143

2003

Volltextzugriff (PDF)

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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

Muscarinic mechanisms in psychotic disorders

Case history: the discovery of fluoxetine hydrochloride (Prozac)

Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder

Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice

M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine

Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication

Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum

1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro

Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice

Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic receptors in vivo in rats

Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors

Biopharmaceutical characterization, metabolism, and brain penetration of the triple reuptake inhibitor amitifadine

Functionally selective M1 muscarinic agonists. 3. Side chain and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles

O3-06-06 Normalization of impaired hippocampal acetylcholine efflux following anti-Aβ antibody administration

M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related central nervous system pathologies

M sub(4) muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

Arachidonic Acid Release in Cell Lines Transfected with Muscarinic Receptors: A Simple Functional Assay to Determine Response of Agonists

Use of M^sub 1^-M^sub 5^ muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype?

PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man

Muscarinic mechanisms of antipsychotic atypicality: Mechanism of atypicality of antipsychotic drugs

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