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Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates

The journal of neuropsychiatry and clinical neurosciences, 2023-01, Vol.35 (1), p.69-76

2023

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Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

Neurotoxicology (Park Forest South), 2024-05, Vol.102, p.12-28

2024

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Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Journal of neurochemistry, 2009-06, Vol.109 (5), p.1427-1439

2009

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Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington’s disease

Molecular therapy, 2023-01, Vol.31 (1), p.282-299

2023

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TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31

Human molecular genetics, 2018-08, Vol.27 (16), p.2893-2912

2018

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Evaluating AlphaFold for Clinical Pharmacology and Pharmacogenetics: A Case-Study of Huntingtin Variants Linked to Huntington’s Disease

The AAPS journal, 2024-09, Vol.26 (6), p.106, Article 106

2024

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Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin―proteasomal and autophagy systems

Human molecular genetics, 2012-12, Vol.21 (24), p.5280-5293

2012

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Apoptosis and Caspases in Neurodegenerative Diseases

The New England journal of medicine, 2003-04, Vol.348 (14), p.1365-1375

Friedlander, Robert M

2003

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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14078-14083

2015

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Long-Term Efficacy and Safety of Deutetrabenazine for Chorea in Huntington’s Disease: Results From the ARC-HD Open-label Study

CNS spectrums, 2021-04, Vol.26 (2), p.164-165

2021

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Therapeutic Effects of Coenzyme Q10 and Remacemide in Transgenic Mouse Models of Huntington's Disease

The Journal of neuroscience, 2002-03, Vol.22 (5), p.1592-1599

2002

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Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease

Human molecular genetics, 2018-07, Vol.27 (14), p.2490-2501

2018

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Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

Movement disorders, 2010-09, Vol.25 (12), p.1924-1928

2010

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Adenosine A 1 receptor agonist, N6-cyclohexyladenosine, attenuates Huntington's disease via stimulation of TrKB/PI3K/Akt/CREB/BDNF pathway in 3-nitropropionic acid rat model

Chemico-biological interactions, 2023-01, Vol.369, p.110288

2023

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A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice

Human molecular genetics, 2016-11, Vol.25 (22), p.4920-4938

2016

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Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

Translational psychiatry, 2013-12, Vol.3 (12), p.e332-e332

2013

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Tauroursodeoxycholic Acid, A Bile Acid, is Neuroprotective in a Transgenic Animal Model of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10671-10676

2002

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Cause or compensation?-Altered neuronal Ca 2+ handling in Huntington's disease

CNS neuroscience & therapeutics, 2018-04, Vol.24 (4), p.301-310

2018

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Immunomodulation – a disease‐modifying avenue for treatment of Huntington's disease?

Journal of neurochemistry, 2016-06, Vol.137 (5), p.670-672

Bjorkqvist, Maria

2016

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Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: Possible role of peroxisome proliferator activated receptor-ϒ (PPARϒ) in Huntington's disease

Pharmacology, biochemistry and behavior, 2010-08, Vol.96 (2), p.115-124

2010

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Behavioral and electrophysiological effects of the adenosine A2A receptor antagonist SCH 58261 in R6/2 Huntington’s disease mice

Neurobiology of disease, 2007-11, Vol.28 (2), p.197-205

2007

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The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin–proteasome system

Human molecular genetics, 2009-08, Vol.18 (16), p.2929-2942

2009

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Apathy Is Not Depression in Huntington's Disease

The journal of neuropsychiatry and clinical neurosciences, 2009-07, Vol.21 (3), p.266-270

2009

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Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 NTR Ligand LM11A-31

Neurotherapeutics, 2021-04, Vol.18 (2), p.1039

2021

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Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington׳s disease

European journal of pharmacology, 2014-06, Vol.732, p.111-122

2014

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Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates

Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington’s disease

TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31

Evaluating AlphaFold for Clinical Pharmacology and Pharmacogenetics: A Case-Study of Huntingtin Variants Linked to Huntington’s Disease

Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin―proteasomal and autophagy systems

Apoptosis and Caspases in Neurodegenerative Diseases

Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Long-Term Efficacy and Safety of Deutetrabenazine for Chorea in Huntington’s Disease: Results From the ARC-HD Open-label Study

Therapeutic Effects of Coenzyme Q10 and Remacemide in Transgenic Mouse Models of Huntington's Disease

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease

Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

Adenosine A 1 receptor agonist, N6-cyclohexyladenosine, attenuates Huntington's disease via stimulation of TrKB/PI3K/Akt/CREB/BDNF pathway in 3-nitropropionic acid rat model

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

Tauroursodeoxycholic Acid, A Bile Acid, is Neuroprotective in a Transgenic Animal Model of Huntington's Disease

Cause or compensation?-Altered neuronal Ca 2+ handling in Huntington's disease

Immunomodulation – a disease‐modifying avenue for treatment of Huntington's disease?

Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: Possible role of peroxisome proliferator activated receptor-ϒ (PPARϒ) in Huntington's disease

Behavioral and electrophysiological effects of the adenosine A2A receptor antagonist SCH 58261 in R6/2 Huntington’s disease mice

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin–proteasome system

Apathy Is Not Depression in Huntington's Disease

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 NTR Ligand LM11A-31

Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington׳s disease

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