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Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Progress in lipid research, 2016-07, Vol.63, p.50-69

Kihara, Akio

2016

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Very long-chain fatty acids: elongation, physiology and related disorders

Journal of biochemistry (Tokyo), 2012-11, Vol.152 (5), p.387-395

Kihara, Akio

2012

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Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Biochimica et biophysica acta, 2014-05, Vol.1841 (5), p.766-772

Kihara, Akio

2014

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Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Journal of lipid research, 2020-06, Vol.61 (6), p.884-895

2020

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Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Journal of lipid research, 2022-07, Vol.63 (7), p.100235-100235, Article 100235

2022

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PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Nature communications, 2017-03, Vol.8 (1), p.14610-14610, Article 14610

2017

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Metabolism of very long-chain Fatty acids: genes and pathophysiology

Biomolecules & Therapeutics, 2014, 22(2), , pp.83-92

2014

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Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

The FASEB journal, 2018-06, Vol.32 (6), p.2966-2978

2018

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Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

eLife, 2020-04, Vol.9

2020

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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

The Journal of biological chemistry, 2016-04, Vol.291 (14), p.7477-7487

2016

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Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Journal of lipid research, 2024-06, Vol.65 (6), p.100550, Article 100550

2024

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Biosynthesis of the anti‐lipid‐microdomain sphingoid base 4,14‐sphingadiene by the ceramide desaturase FADS3

The FASEB journal, 2020-02, Vol.34 (2), p.3318-3335

2020

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Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases

The Journal of biological chemistry, 2021-01, Vol.296, p.100605-100605, Article 100605

2021

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Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

The FASEB journal, 2022-04, Vol.36 (4), p.e22216-n/a

2022

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Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

Journal of dermatological science, 2021-01, Vol.101 (1), p.69-71

2021

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Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

Journal of dermatological science, 2022-08, Vol.107 (2), p.89-94

2022

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Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (25), p.7707-7712

2015

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A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells

Biochimica et biophysica acta, 2012-07, Vol.1821 (7), p.1031-1037

2012

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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.263-271

2005

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Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

PloS one, 2014-07, Vol.9 (7), p.e101823-e101823

2014

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Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Biochemical and biophysical research communications, 2013-12, Vol.442 (3-4), p.195-201

2013

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Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals

International journal of molecular sciences, 2024-08, Vol.25 (15), p.8291

2024

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Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Journal of lipid research, 2014-03, Vol.55 (3), p.524-530

2014

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Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24736-24748

2014

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Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

FEBS letters, 2011-10, Vol.585 (20), p.3337-3341

2011

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Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Very long-chain fatty acids: elongation, physiology and related disorders

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Metabolism of very long-chain Fatty acids: genes and pathophysiology

Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Biosynthesis of the anti‐lipid‐microdomain sphingoid base 4,14‐sphingadiene by the ceramide desaturase FADS3

Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases

Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

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