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Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT6 Receptor Agonists and Antagonists

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.353-356

2005

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Introduction

La Presse médicale (1983), 2015-11, Vol.44 Suppl 1, p.S1

Groupe d'étude MACVIA-LR

2015

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1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5499-5502

2004

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5-Fluoro-2-methyl- N -[4-(5 H -pyrrolo[2,1- c ]- [1,4]benzodiazepin-10(11 H )-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985): An Orally Active Arginine Vasopressin Antagonist with Selectivity for V 2 Receptors

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2442-2444

1998

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(4-Substituted-phenyl)-(5 H-10,11-dihydro-pyrrolo [2,1- c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.5003-5006

2005

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6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-07, Vol.4 (14), p.1703-1708

1994

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6-Substituted Quinazolinone Angiotensin II Receptor Antagonists

Bioorganic & medicinal chemistry letters, 1994-08, Vol.4 (15), p.1819-1824

1994

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2,3,6-Substituted quinazolinones as angiotensin II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-05, Vol.4 (9), p.1135-1140

1994

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Substituted 4H-pyrido[1,2-a]pyrimidin-4-one angiotensin II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.183-188

1994

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New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D 2 Template

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.271-274

2002

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Discovery of 5-Arylsulfonamido-3-(pyrrolidin-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT sub(6) Receptor Agonists and Antagonists

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.353-356

2005

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VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist

Advances in experimental medicine and biology, 1998, Vol.449, p.439

1998

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New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D 2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4235-4256

1997

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4,10-Dihydro-5h-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4h-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1733-1736

1999

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New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D 2 template

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2593-2598

1999

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New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2593-2598

1999

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New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives

Tetrahedron, 1998-06, Vol.54 (25), p.7081-7108

1998

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The separation of 3H-Benzodiazepine binding sites in brain and of benzodiazepine pharmacological properties

Pharmacology, biochemistry and behavior, 1983-02, Vol.18 (2), p.311-318

1983

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Evidence that benzodiazepine receptors reside on cerebellar purkinje cells: Studies with “nervous” mutant mice

Life sciences (1973), 1978-11, Vol.23 (22), p.2213-2217

1978

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Chapitre 31 - Cytomégalovirus et grossesse

Le diagnostic prénatal en pratique, p.325-337

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Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

Pharmacology, biochemistry and behavior, 1979-05, Vol.10 (5), p.825-830

1979

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New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N'-phenylpiperazine dopaminergic template

Bioorganic & medicinal chemistry letters, 1998, Vol.8 (19), p.2675-2680

1998

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Coronary artery stenosis in rats affect β-adrenergic receptor signaling in myocytes

Cardiovascular research, 1997, Vol.33 (1), p.98-109

1997

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New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.295-300

1998

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Coronary artery constriction in rats affects the activation of 1 adrenergic receptors in cardiac myocytes

Cardiovascular research, 1994-07, Vol.28 (7), p.1070-1082

1994

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Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT6 Receptor Agonists and Antagonists

Introduction

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

5-Fluoro-2-methyl- N -[4-(5 H -pyrrolo[2,1- c ]- [1,4]benzodiazepin-10(11 H )-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985): An Orally Active Arginine Vasopressin Antagonist with Selectivity for V 2 Receptors

(4-Substituted-phenyl)-(5 H-10,11-dihydro-pyrrolo [2,1- c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators

6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists

6-Substituted Quinazolinone Angiotensin II Receptor Antagonists

2,3,6-Substituted quinazolinones as angiotensin II receptor antagonists

Substituted 4H-pyrido[1,2-a]pyrimidin-4-one angiotensin II receptor antagonists

New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D 2 Template

Discovery of 5-Arylsulfonamido-3-(pyrrolidin-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT sub(6) Receptor Agonists and Antagonists

VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist

New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D 2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

4,10-Dihydro-5h-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4h-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D 2 template

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives

The separation of 3H-Benzodiazepine binding sites in brain and of benzodiazepine pharmacological properties

Evidence that benzodiazepine receptors reside on cerebellar purkinje cells: Studies with “nervous” mutant mice

Chapitre 31 - Cytomégalovirus et grossesse

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N'-phenylpiperazine dopaminergic template

Coronary artery stenosis in rats affect β-adrenergic receptor signaling in myocytes

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Coronary artery constriction in rats affects the activation of 1 adrenergic receptors in cardiac myocytes

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