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Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model

ACS chemical neuroscience, 2023-10, Vol.14 (20), p.3826-3838

2023

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Virtual screening and in vitro experiments highlight cannabidiol as a drug‐like phosphodiesterase 9 inhibitor

The European journal of neuroscience, 2023-06, Vol.57 (12), p.1954-1965

2023

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Cannabidiol preferentially binds TRPV2: a novel mechanism of action

Neural regeneration research, 2022-12, Vol.17 (12), p.2693-2694

2022

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Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model

Neurobiology of disease, 2022-11, Vol.174, p.105895-105895, Article 105895

2022

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Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol

Toxics (Basel), 2022-01, Vol.10 (2), p.48

2022

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Ethanol neurotoxicity is mediated by changes in expression, surface localization and functional properties of glutamate AMPA receptors

Journal of neurochemistry, 2021-06, Vol.157 (6), p.2106-2118

2021

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Tolerance Induced by (S)-3,5-Dihydroxyphenylglycine Postconditioning is Mediated by the PI3K/Akt/GSK3β Signalling Pathway in an In Vitro Model of Cerebral Ischemia

Neuroscience, 2020-05, Vol.433, p.221-229

2020

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Reconsolidation of sucrose instrumental memory in rats: The role of retrieval context

Brain research, 2019-07, Vol.1714, p.193-201

2019

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Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures

Frontiers in neuroscience, 2019-01, Vol.12, p.1053-1053

2019

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Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress

Neural regeneration research, 2019-01, Vol.14 (1), p.65-66

2019

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The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats

Neurobiology of learning and memory, 2018-10, Vol.154, p.87-96

2018

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Neuroprotective effects of topiramate and memantine in combination with hypothermia in hypoxic-ischemic brain injury in vitro and in vivo

Neuroscience letters, 2018-03, Vol.668, p.103-107

2018

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Glutamate and Stroke: From NMDA to mGlu Receptors and Beyond

Rational Basis for Clinical Translation in Stroke Therapy, 2015, p.350-363

2015

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Activation of the histaminergic H 3 receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults

Journal of neurochemistry, 2009-09, Vol.110 (5), p.1469-1478

2009

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Involvement of endocannabinoid signaling in the neuroprotective effects of subtype 1 metabotropic glutamate receptor antagonists in models of cerebral ischemia

International review of neurobiology, 2009, Vol.85, p.337-350

2009

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mGlu1α receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain

Neuropharmacology, 2008-09, Vol.55 (4), p.428-439

2008

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GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex

Journal of neurochemistry, 2008-06, Vol.105 (5), p.1781-1793

2008

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Neuroprotective Effects of Propofol in Acute Cerebral Injury

CNS drug reviews, 2007-09, Vol.13 (3), p.333-351

2007

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Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures

Neuropharmacology, 2005, Vol.49, p.80-88

2005

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Differential role of poly(ADP-ribose) polymerase-1 in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro

Molecular and cellular neuroscience, 2004-01, Vol.25 (1), p.172-180

2004

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An activity-dependent spermine-mediated mechanism that modulates glutamate transmission

Trends in neurosciences (Regular ed.), 2003, Vol.26 (1), p.9-11

Pellegrini-Giampietro, Domenico E

2003

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1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia

The European journal of neuroscience, 1999-10, Vol.11 (10), p.3637-3647

1999

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The GluR2 (GluR-B) hypothesis : Ca2+-permeable AMPA receptors in neurological disorders

Trends in neurosciences (Regular ed.), 1997-10, Vol.20 (10), p.464-470

1997

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Are Ca 2+-permeable kainate/AMPA receptors more abundant in immature brain?

Neuroscience letters, 1992-09, Vol.144 (1), p.65-69

1992

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Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model

Virtual screening and in vitro experiments highlight cannabidiol as a drug‐like phosphodiesterase 9 inhibitor

Cannabidiol preferentially binds TRPV2: a novel mechanism of action

Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model

Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol

Ethanol neurotoxicity is mediated by changes in expression, surface localization and functional properties of glutamate AMPA receptors

Tolerance Induced by (S)-3,5-Dihydroxyphenylglycine Postconditioning is Mediated by the PI3K/Akt/GSK3β Signalling Pathway in an In Vitro Model of Cerebral Ischemia

Reconsolidation of sucrose instrumental memory in rats: The role of retrieval context

Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures

Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress

The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats

Neuroprotective effects of topiramate and memantine in combination with hypothermia in hypoxic-ischemic brain injury in vitro and in vivo

Glutamate and Stroke: From NMDA to mGlu Receptors and Beyond

Activation of the histaminergic H 3 receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults

Involvement of endocannabinoid signaling in the neuroprotective effects of subtype 1 metabotropic glutamate receptor antagonists in models of cerebral ischemia

mGlu1α receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain

GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex

Neuroprotective Effects of Propofol in Acute Cerebral Injury

Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures

Differential role of poly(ADP-ribose) polymerase-1 in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro

An activity-dependent spermine-mediated mechanism that modulates glutamate transmission

1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia

The GluR2 (GluR-B) hypothesis : Ca2+-permeable AMPA receptors in neurological disorders

Are Ca 2+-permeable kainate/AMPA receptors more abundant in immature brain?

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