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Activation and regulation of purinergic P2X receptor channels

Pharmacological reviews, 2011-09, Vol.63 (3), p.641

2011

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Purinergic P2X receptors: Structural models and analysis of ligand-target interaction

European journal of medicinal chemistry, 2015-01, Vol.89, p.561-580

2015

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X-ray structures define human P2X(3) receptor gating cycle and antagonist action

Nature (London), 2016-10, Vol.538 (7623), p.66

2016

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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

Pharmacological reviews, 2014-07, Vol.66 (3), p.638-675

2014

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P2X7 receptor antagonism: Implications in diabetic retinopathy

Biochemical pharmacology, 2017-08, Vol.138, p.130-139

2017

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P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

European journal of pharmacology, 2021-09, Vol.906, p.174235-174235, Article 174235

2021

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Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128384-128384, Article 128384

2021

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Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors

Molecular pharmacology, 2022-01, Vol.101 (1), p.33-44

2022

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P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

Glia, 2014-04, Vol.62 (4), p.592-607

2014

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Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

The Journal of neuroscience, 2016-06, Vol.36 (22), p.5920-5932

2016

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P2X7 receptor: an emerging target in central nervous system diseases

Trends in pharmacological sciences (Regular ed.), 2014-10, Vol.35 (10), p.537-547

2014

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Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke

Experimental neurology, 2020-07, Vol.329, p.113308-113308, Article 113308

2020

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Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Nature communications, 2016-02, Vol.7 (1), p.10555-10555, Article 10555

2016

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Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists

European journal of medicinal chemistry, 2021-12, Vol.226, p.113838-113838, Article 113838

2021

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P2X receptors: Insights from the study of the domestic dog

Neuropharmacology, 2023-02, Vol.224, p.109358, Article 109358

2023

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Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

Current medicinal chemistry, 2024-01, Vol.31 (11), p.1361

2024

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Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

Molecular pharmacology, 2019-09, Vol.96 (3), p.355-363

2019

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Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

Biochemical pharmacology, 2024-04, Vol.222, p.116046-116046, Article 116046

2024

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The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

Oncogene, 2019-05, Vol.38 (19), p.3636-3650

2019

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A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders

Phytomedicine (Stuttgart), 2024-06, Vol.128, p.155334-155334, Article 155334

2024

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Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.2272-2290

2021

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The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

Purinergic signalling, 2018-03, Vol.14 (1), p.1-18

2018

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CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury

Journal of hepatology, 2017-10, Vol.67 (4), p.716-726

2017

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Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.13967-13987

2022

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Activation and regulation of purinergic P2X receptor channels

Purinergic P2X receptors: Structural models and analysis of ligand-target interaction

X-ray structures define human P2X(3) receptor gating cycle and antagonist action

The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

P2X7 receptor antagonism: Implications in diabetic retinopathy

P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

P2X7 receptor: an emerging target in central nervous system diseases

Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke

4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists

P2X receptors: Insights from the study of the domestic dog

Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury

Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists

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