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Hemoglobin: Structure, Function and Allostery

Sub-cellular biochemistry, 2020, Vol.94, p.345-382

2020

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New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

British journal of haematology, 2016-10, Vol.175 (1), p.24-30

2016

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Therapeutic Strategies to Alter the Oxygen Affinity of Sickle Hemoglobin

Hematology/oncology clinics of North America, 2014-04, Vol.28 (2), p.217-231

2014

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Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

International journal of molecular sciences, 2022-07, Vol.23 (13), p.7448

2022

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Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies

Biochimie, 2021-04, Vol.183, p.18-29

2021

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Elucidating the Interaction between Pyridoxine 5'-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme

International journal of molecular sciences, 2022-12, Vol.24 (1), p.642

2022

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Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

Molecular pharmaceutics, 2017-10, Vol.14 (10), p.3499-3511

2017

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The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Medicinal research reviews, 2024-11, Vol.44 (6), p.2707-2729

2024

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A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

Molecular pharmaceutics, 2018-05, Vol.15 (5), p.1954-1963

2018

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Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Nature communications, 2016-07, Vol.7 (1), p.12086-12086, Article 12086

2016

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On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

The FEBS journal, 2014-01, Vol.281 (1), p.129-145

2014

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Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Expert opinion on therapeutic patents, 2022-02, Vol.32 (2), p.115-130

2022

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Correction: Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Disease models & mechanisms, 2023-10, Vol.16 (10)

2023

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Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

International journal of nanomedicine, 2020-01, Vol.15, p.4001-4020

2020

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Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway

The FEBS journal, 2023-12, Vol.290 (23), p.5628-5651

2023

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Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14724-14739

2020

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Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability

International journal of pharmaceutics, 2023-05, Vol.639, p.122966-122966, Article 122966

2023

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Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation

Journal of pharmaceutical and biomedical analysis, 2023-01, Vol.223, p.115152-115152, Article 115152

2023

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Hemoglobin–ligand binding: Understanding Hb function and allostery on atomic level

Biochimica et biophysica acta, 2011-06, Vol.1814 (6), p.797-809

2011

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Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

The Journal of biological chemistry, 2013-01, Vol.288 (1), p.132-140

2013

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Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

Pharmaceuticals (Basel, Switzerland), 2022-01, Vol.15 (1), p.68

2022

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Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Scientific reports, 2017-11, Vol.7 (1), p.15281-16, Article 15281

2017

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Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.802-818

2021

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Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

Biology (Basel, Switzerland), 2023-03, Vol.12 (4), p.504

2023

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New Antiproliferative Triflavanone from Thymelaea hirsuta -Isolation, Structure Elucidation and Molecular Docking Studies

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.739

2021

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Hemoglobin: Structure, Function and Allostery

New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

Therapeutic Strategies to Alter the Oxygen Affinity of Sickle Hemoglobin

Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies

Elucidating the Interaction between Pyridoxine 5'-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Correction: Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway

Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability

Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation

Hemoglobin–ligand binding: Understanding Hb function and allostery on atomic level

Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site

Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

New Antiproliferative Triflavanone from Thymelaea hirsuta -Isolation, Structure Elucidation and Molecular Docking Studies

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