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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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Sar1 GTPase Activity Is Regulated by Membrane Curvature

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1014-1027

2016

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Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3685-3699

2018

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Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4822-4835

2020

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IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES

The Journal of biological chemistry, 2016-12, Vol.291 (51), p.26364-26376

2016

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Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

The Journal of biological chemistry, 2019-11, Vol.294 (44), p.16198-16213

2019

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LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

The Journal of biological chemistry, 2017-09, Vol.292 (36), p.14989-15001

2017

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Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier

The Journal of biological chemistry, 2015-02, Vol.290 (7), p.4097-4109

2015

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Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

The Journal of biological chemistry, 2015-05, Vol.290 (20), p.12879-12898

2015

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Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function

The Journal of biological chemistry, 2020-12, Vol.295 (52), p.18105-18121

2020

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IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity

The Journal of biological chemistry, 2016-09, Vol.291 (37), p.19261-19273

2016

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IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

The Journal of biological chemistry, 2012-06, Vol.287 (27), p.22483-22496

2012

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Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1)

The Journal of biological chemistry, 2015-09, Vol.290 (39), p.23984-23996

2015

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Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

The Journal of biological chemistry, 2020-01, Vol.295 (4), p.1105-1119

2020

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Absence of IQGAP1 Protein Leads to Insulin Resistance

The Journal of biological chemistry, 2017-02, Vol.292 (8), p.3273-3289

2017

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Ca2+-dependent Monomer and Dimer Formation Switches CAPRI Protein between Ras GTPase-activating Protein (GAP) and RapGAP Activities

The Journal of biological chemistry, 2011-06, Vol.286 (22), p.19905-19916

2011

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S100P Is a Novel Interaction Partner and Regulator of IQGAP1

The Journal of biological chemistry, 2011-03, Vol.286 (9), p.7227-7238

2011

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Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons

The Journal of biological chemistry, 2010-09, Vol.285 (36), p.28200-28209

2010

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AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration

The Journal of biological chemistry, 2011-11, Vol.286 (45), p.39269-39281

2011

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AIP1/DAB2IP, a Novel Member of the Ras-GAP Family, Transduces TRAF2-induced ASK1-JNK Activation

The Journal of biological chemistry, 2004-10, Vol.279 (43), p.44955-44965

2004

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IQGAP1 Protein Binds Human Epidermal Growth Factor Receptor 2 (HER2) and Modulates Trastuzumab Resistance

The Journal of biological chemistry, 2011-08, Vol.286 (34), p.29734-29747

2011

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Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation

The Journal of biological chemistry, 2001-12, Vol.276 (52), p.49289-49298

2001

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IQGAP1 Binds Rap1 and Modulates Its Activity

The Journal of biological chemistry, 2007-07, Vol.282 (28), p.20752-20762

2007

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IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling

The Journal of biological chemistry, 2008-08, Vol.283 (34), p.22972-22982

2008

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Neurofibromatosis Type I Tumor Suppressor Neurofibromin Regulates Neuronal Differentiation via Its GTPase-activating Protein Function toward Ras

The Journal of biological chemistry, 2003-07, Vol.278 (29), p.26958-26969

2003

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

Sar1 GTPase Activity Is Regulated by Membrane Curvature

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier

Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function

IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1)

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Absence of IQGAP1 Protein Leads to Insulin Resistance

Ca2+-dependent Monomer and Dimer Formation Switches CAPRI Protein between Ras GTPase-activating Protein (GAP) and RapGAP Activities

S100P Is a Novel Interaction Partner and Regulator of IQGAP1

Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons

AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration

AIP1/DAB2IP, a Novel Member of the Ras-GAP Family, Transduces TRAF2-induced ASK1-JNK Activation

IQGAP1 Protein Binds Human Epidermal Growth Factor Receptor 2 (HER2) and Modulates Trastuzumab Resistance

Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation

IQGAP1 Binds Rap1 and Modulates Its Activity

IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling

Neurofibromatosis Type I Tumor Suppressor Neurofibromin Regulates Neuronal Differentiation via Its GTPase-activating Protein Function toward Ras

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