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Targeting protein aggregation for the treatment of degenerative diseases

Nature reviews. Drug discovery, 2015-11, Vol.14 (11), p.759-780

2015

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Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12184-12189

2017

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Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis

Circulation (New York, N.Y.), 2016-06, Vol.133 (24), p.2404-2412

2016

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Amyloid neuropathies

Current opinion in neurology, 2012-10, Vol.25 (5), p.564-572

2012

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Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment

Analytical chemistry (Washington), 2020-03, Vol.92 (5), p.3751-3757

2020

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Nucleic acids research, 2014-07, Vol.42 (13), p.8796-8807

2014

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Directional thyroid hormone distribution via the blood stream to target sites

Molecular and cellular endocrinology, 2017-12, Vol.458, p.16-21

2017

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Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

Science translational medicine, 2017-09, Vol.9 (407)

2017

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Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

European journal of heart failure, 2022-09, Vol.24 (9), p.1700-1712

2022

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Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells

The Journal of immunology (1950), 2019-02, Vol.202 (3), p.991-1002

2019

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Transthyretin (TTR) Cardiac Amyloidosis

Circulation (New York, N.Y.), 2012-09, Vol.126 (10), p.1286-1300

2012

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Domino Liver Transplantation (DLT) and De Novo Familial Amyloid Polyneuropathy (FAP): The Portuguese Experience (S58.004)

Neurology, 2023-07, Vol.101 (3), p.147-147

2023

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A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH

The Journal of biological chemistry, 2019-07, Vol.294 (29), p.11259-11275

2019

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Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis

The FEBS journal, 2024-04, Vol.291 (8), p.1732-1743

2024

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Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

Acta neuropathologica, 2009-07, Vol.118 (1), p.115-130

2009

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Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Cell reports (Cambridge), 2013-04, Vol.3 (4), p.1279-1292

2013

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Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae

Aquatic toxicology, 2012-04, Vol.110-111, p.141-148

2012

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Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization

Scientific reports, 2017-02, Vol.7 (1), p.42880, Article 42880

2017

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Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: A population-based autopsy study

Annals of medicine (Helsinki), 2008, Vol.40 (3), p.232-239

2008

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The protofilament substructure of amyloid fibrils

Journal of molecular biology, 2000-07, Vol.300 (5), p.1033-1039

2000

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Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation

The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102597, Article 102597

2022

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Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression

Orphanet journal of rare diseases, 2021-10, Vol.16 (1), p.411-411, Article 411

2021

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Emerging treatments for amyloidosis

Kidney international, 2015-03, Vol.87 (3), p.516-526

2015

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Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

Human molecular genetics, 2012-07, Vol.21 (13), p.2973-2990

2012

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Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole

Aquatic toxicology, 2013-08, Vol.138-139, p.35-42

2013

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Targeting protein aggregation for the treatment of degenerative diseases

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis

Amyloid neuropathies

Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Directional thyroid hormone distribution via the blood stream to target sites

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells

Transthyretin (TTR) Cardiac Amyloidosis

Domino Liver Transplantation (DLT) and De Novo Familial Amyloid Polyneuropathy (FAP): The Portuguese Experience (S58.004)

A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH

Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae

Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization

Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: A population-based autopsy study

The protofilament substructure of amyloid fibrils

Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation

Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression

Emerging treatments for amyloidosis

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole

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