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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Cell, 2020-10, Vol.183 (2), p.490-502.e18

2020

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Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Scientific reports, 2017-02, Vol.7 (1), p.42374-42374, Article 42374

2017

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Cell reports (Cambridge), 2020-06, Vol.31 (12), p.107809, Article 107809

2020

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Design and Synthesis of Orally Bioavailable 4‑Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7651-7666

2016

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

ACS medicinal chemistry letters, 2014-09, Vol.5 (9), p.993-998

2014

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Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors

European journal of medicinal chemistry, 2017-09, Vol.138, p.1147-1157

2017

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic

Cells (Basel, Switzerland), 2022-11, Vol.11 (23), p.3868

2022

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Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.359-362

2015

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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.802-806

2016

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Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1789-1808

2012

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Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.558-562

2016

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Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection

ACS infectious diseases, 2018-03, Vol.4 (3), p.257-277

2018

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Soluble epoxide hydrolase inhibitors: a patent review

Expert opinion on therapeutic patents, 2010-07, Vol.20 (7), p.941-956

Shen, Hong C

2010

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Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6003-6014

2019

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Gold-catalyzed formation of heterocycles – an enabling new technology for medicinal chemistry

Drug discovery today. Technologies, 2013-03, Vol.10 (1), p.e3-e14

2013

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Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10619-10634

2018

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Discovery of Pyrido[2,3‑b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9623-9649

2020

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Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.4253-4270

2023

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Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.14116-14132

2023

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Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10228-10241

2018

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Asymmetric Synthesis and Application of Homologous Pyrroline-2-alkylboronic Acids: Identification of the B-N Distance for Eliciting Bifunctional Catalysis of an Asymmetric Aldol Reaction

Asian journal of organic chemistry, 2014-04, Vol.3 (4), p.470-479

2014

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Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.10938-10955

2022

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A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10352-10361

2019

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Design and Synthesis of Orally Bioavailable 4‑Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic

Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection

Soluble epoxide hydrolase inhibitors: a patent review

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Gold-catalyzed formation of heterocycles – an enabling new technology for medicinal chemistry

Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Discovery of Pyrido[2,3‑b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Asymmetric Synthesis and Application of Homologous Pyrroline-2-alkylboronic Acids: Identification of the B-N Distance for Eliciting Bifunctional Catalysis of an Asymmetric Aldol Reaction

Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection

Discovery and Pre-Clinical Characterization of Third-Generation 4‑H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles

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