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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

1, 2018

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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Nucleic acids research, 2014-11, Vol.42 (20), p.12555-12569

2014

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Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Oncology reports, 2006-09, Vol.16 (3), p.617-624

2006

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Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

Anticancer research, 2007-09, Vol.27 (5A), p.3459-3464

2007

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Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure–activity relationship

Biochemical pharmacology, 2005-03, Vol.69 (6), p.903-912

2005

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Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

Chemical & Pharmaceutical Bulletin, 2007, Vol.55 (1), p.64-71

2007

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Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells

Anticancer research, 2016-02, Vol.36 (2), p.683

2016

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Drug Selectivity

2017

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A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages

Natural product communications, 2016-10, Vol.11 (10), p.1437-1440

2016

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Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells

Experimental hematology, 2006-10, Vol.34 (10), p.1377-1384

2006

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Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells : Inhibition of ribonucleotide reductase activity

Oncology reports, 2008-06, Vol.19 (6), p.1621-1626

2008

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No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells

Atherosclerosis, 2007-11, Vol.195 (1), p.e58-e64

2007

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Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

Investigational new drugs, 2009-10, Vol.27 (5), p.393-401

2009

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Completion of the Spectroscopical Data for the Synthesis of DIMBOA

Scientia pharmaceutica, 2005-09, Vol.73 (3), p.95-100

2005

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Pharmacophore Generation for Multiple Ligands

Drug Selectivity, 2017, p.275-312

2017

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A Personal Foreword

Drug Selectivity, 2018

Handler, Norbert

2018

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N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine

International journal of oncology, 2007-11, Vol.31 (5), p.1261

2007

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Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds

Oncology reports, 2008-03, Vol.19 (3), p.801-810

2008

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Cytotoxic and proapototic activity of reveratrol analogues in breast cancer cell lines structure activity relationship (SAR)

The FASEB journal, 2006-03, Vol.20 (5), p.A1141-A1142

2006

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Part II Selectivity of Marketed Drugs

Drug Selectivity, 2018

Handler, Norbert

2018

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Part I Introduction

Drug Selectivity, 2018

Handler, Norbert

2018

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Part III Unselective Drugs in Drug Discovery

Drug Selectivity, 2018

Handler, Norbert

2018

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Part IV Therapeutic Areas for Designed Multiple Ligands

Drug Selectivity, 2018

Handler, Norbert

2018

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EULA

Drug Selectivity, 2018

Handler, Norbert

2018

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Multiple Ligands in Neurodegenerative Diseases

Drug Selectivity, 2017, p.477-508

2017

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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure–activity relationship

Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells

Drug Selectivity

A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages

Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells

Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells : Inhibition of ribonucleotide reductase activity

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

Completion of the Spectroscopical Data for the Synthesis of DIMBOA

Pharmacophore Generation for Multiple Ligands

A Personal Foreword

N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine

Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds

Cytotoxic and proapototic activity of reveratrol analogues in breast cancer cell lines structure activity relationship (SAR)

Part II Selectivity of Marketed Drugs

Part I Introduction

Part III Unselective Drugs in Drug Discovery

Part IV Therapeutic Areas for Designed Multiple Ligands

EULA

Multiple Ligands in Neurodegenerative Diseases

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