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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature

PloS one, 2022-09, Vol.17 (9), p.e0268590-e0268590

2022

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Prospective de novo drug design with deep interactome learning

Nature communications, 2024-04, Vol.15 (1), p.3408-3408

2024

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Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice

Biomedicine & pharmacotherapy, 2024-05, Vol.174, p.116473-116473, Article 116473

2024

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Editorial: Therapeutic potential of the cannabinoid CB2 receptor

Frontiers in pharmacology, 2022-10, Vol.13, p.1039564-1039564

2022

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Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Frontiers in pharmacology, 2023-08, Vol.14, p.1158091-1158091

2023

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Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

Frontiers in pharmacology, 2022-04, Vol.13, p.841766-841766

2022

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Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether

Pharmaceutical patent analyst, 2021-07, Vol.10 (4), p.175-177

Grether, Uwe

2021

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An Enzyme-Labile Safety Catch Linker for Synthesis on a Soluble Polymeric Support

Chemistry : a European journal, 2001-03, Vol.7 (5), p.959-971

2001

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The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17656-17689

2021

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Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology

Chembiochem : a European journal of chemical biology, 2023-06, Vol.24 (11), p.e202300121-n/a

2023

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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Current topics in medicinal chemistry, 2011-08, Vol.11 (15), p.1902

2011

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Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Pharmacological reviews, 2023-09, Vol.75 (5), p.885

2023

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NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

The EMBO journal, 2018-08, Vol.37 (16), p.n/a

2018

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Identification of (R)-[18F]YH134 as a promising reversible MAGL PET tracer and the impact of peripheral MAGL blockade on its brain uptake

Nuclear medicine and biology, 2023-11, Vol.126-127, p.108546, Article 108546

2023

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Development of reversible monoacylglycerol lipase PET tracers with improved brain uptake

Nuclear medicine and biology, 2021-05, Vol.96-97, p.S36

2021

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SP-005 - Development of reversible monoacylglycerol lipase PET tracers with improved brain uptake

Nuclear medicine and biology, 2021-05, Vol.96-97, p.S36-S36

2021

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Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2191-2207

2022

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Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10287-10306

2020

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Identification of ( R )-[ 18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development

The Journal of nuclear medicine (1978), 2024-02, Vol.65 (2), p.300

2024

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Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning

Nature chemistry, 2024-02, Vol.16 (2), p.239

2024

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O-04 - Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold

Nuclear medicine and biology, 2022-05, Vol.108-109, p.S5-S6

2022

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Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold

Nuclear medicine and biology, 2022-05, Vol.108-109, p.S5-S6

2022

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Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11165-11181

2019

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Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases

Chembiochem : a European journal of chemical biology, 2024-04, Vol.25 (7), p.e202300819-n/a

2024

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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature

Prospective de novo drug design with deep interactome learning

Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice

Editorial: Therapeutic potential of the cannabinoid CB2 receptor

Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether

An Enzyme-Labile Safety Catch Linker for Synthesis on a Soluble Polymeric Support

The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO

Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

Identification of (R)-[18F]YH134 as a promising reversible MAGL PET tracer and the impact of peripheral MAGL blockade on its brain uptake

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Development of reversible monoacylglycerol lipase PET tracers with improved brain uptake

SP-005 - Development of reversible monoacylglycerol lipase PET tracers with improved brain uptake

Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Identification of ( R )-[ 18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development

Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning

O-04 - Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold

Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold

Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases

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