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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Nature (London), 2016-09, Vol.537 (7619), p.214-219

2016

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Late-stage oxidative C(sp3)–H methylation

Nature (London), 2020-04, Vol.580 (7805), p.621-627

2020

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie International Edition, 2016-08, Vol.55 (33), p.9758-9762

International ed. in English, 2016

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Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.537-550

2023

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Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Biotechnology journal, 2021-04, Vol.16 (4), p.e2000315-n/a

2021

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Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Organic process research & development, 2022-03, Vol.26 (3), p.616-623

2022

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Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Tetrahedron letters, 2013-12, Vol.54 (51), p.7065-7068

2013

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

Chemical research in toxicology, 2011-02, Vol.24 (2), p.269-278

2011

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie, 2016-08, Vol.128 (33), p.9910-9914

2016

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Organic process research & development, 2024-10, Vol.28 (10), p.3801-3807

2024

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Organic process research & development, 2021-06, Vol.25 (6), p.1440-1453

2021

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Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Journal of organic chemistry, 1998-07, Vol.63 (15), p.5088-5093

1998

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A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

Tetrahedron letters, 2006-10, Vol.47 (44), p.7677-7680

2006

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ChemInform Abstract: Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

ChemInform, 2016-11, Vol.47 (50), p.no-no

2016

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An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Tetrahedron letters, 2000, Vol.41 (32), p.6041-6044

2000

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The Discovery of Fluoropyridine-Based Inhibitors of the Factor VIIa/TF Complex

ChemInform, 2006-01, Vol.37 (4), p.no-no

2006

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Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (20), p.5567-5572

2007

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Model Studies on the Synthesis of Hennoxazole A

Synlett, 1995-05, Vol.1995 (5), p.415-416

1995

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The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolid ine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Chemical biology & drug design, 2007-08, Vol.70 (2), p.100-112

2007

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ChemInform Abstract: Expedient Synthesis of Novel β-Ketoesters from the Mizoroki-Heck Coupling of Ethyl 3-Ethoxyacrylate with Aryl and Pyridyl Halides

ChemInform, 2014-04, Vol.45 (14), p.no-no

2014

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ChemInform Abstract: Expedient Synthesis of Novel [beta]-Ketoesters from the Mizoroki--Heck Coupling of Ethyl 3-Ethoxyacrylate with Aryl and Pyridyl Halides

ChemInform, 2014-04, Vol.45 (14)

2014

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Studies towards the synthesis of hennoxazole a

Kohrt, Jeffrey Thomas

1996

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FUSED PYRAZOLE SYNTHESIS BY N-N BOND FORMATION: THE PYRAZOLO[5,1-b]BENZOTHIAZOLE SYSTEM

Heterocyclic communications, 1997, Vol.3 (3), p.201-206

1997

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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Late-stage oxidative C(sp3)–H methylation

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

ChemInform Abstract: Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

The Discovery of Fluoropyridine-Based Inhibitors of the Factor VIIa/TF Complex

Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Model Studies on the Synthesis of Hennoxazole A

The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolid ine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

ChemInform Abstract: Expedient Synthesis of Novel β-Ketoesters from the Mizoroki-Heck Coupling of Ethyl 3-Ethoxyacrylate with Aryl and Pyridyl Halides

ChemInform Abstract: Expedient Synthesis of Novel [beta]-Ketoesters from the Mizoroki--Heck Coupling of Ethyl 3-Ethoxyacrylate with Aryl and Pyridyl Halides

Studies towards the synthesis of hennoxazole a

FUSED PYRAZOLE SYNTHESIS BY N-N BOND FORMATION: THE PYRAZOLO[5,1-b]BENZOTHIAZOLE SYSTEM

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