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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

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Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BMC pharmacology, 2012-05, Vol.12 (1), p.5-5, Article 5

2012

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

Volltextzugriff (PDF)

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

Volltextzugriff (PDF)

Species differences in distribution and prediction of human V(ss) from preclinical data

Drug metabolism and disposition, 2011-11, Vol.39 (11), p.2103

2011

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An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes

Drug metabolism letters, 2008-01, Vol.2 (1), p.51

2008

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Esterase activities in the blood, liver and intestine of several preclinical species and humans

Drug metabolism letters, 2009-04, Vol.3 (2), p.70

2009

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Long-acting [kappa] opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BMC pharmacology, 2012-01, Vol.12 (1)

2012

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Prediction of V(ss) from in vitro tissue-binding studies

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.115

2010

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Leaders in Sales and Sales Management

The Journal of personal selling & sales management, 1981-01, Vol.1 (1), p.90-91

1981

Volltextzugriff (PDF)

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

The Journal of physiology, 2018-12, Vol.596 (23), p.5535-5569

2018

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Comparison of Methods of Initial Ascertainment in 58 Cases of Propionic Acidemia Enrolled in the Inborn Errors of Metabolism Information System Reveals Significant Differences in Time to Evaluation and Symptoms at Presentation

The Journal of pediatrics, 2017-01, Vol.180, p.200-205.e8

2017

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Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

Molecular genetics and metabolism, 2016-08, Vol.118 (4), p.272-281

2016

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Measuring Pediatric Hospital Readmission Rates to Drive Quality Improvement

Academic pediatrics, 2014-09, Vol.14 (5), p.S39-S46

2014

Volltextzugriff (PDF)

Delays in melanoma presentation during the COVID-19 pandemic: A nationwide multi-institutional cohort study

Journal of the American Academy of Dermatology, 2022-11, Vol.87 (5), p.1217-1219

2022

Volltextzugriff (PDF)

Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments

Journal of neuroimmunology, 2013-11, Vol.264 (1), p.106-113

2013

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Decomposition of monazite concentrate in sulphuric acid

Canadian metallurgical quarterly, 2018-10, Vol.57 (4), p.422-433

2018

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Major features and forcing of high-latitude northern hemisphere atmospheric circulation using a 110,000-year-long glaciochemical series

Journal of Geophysical Research, Washington, DC, 1997-11, Vol.102 (C12), p.26345-26366

1997

Volltextzugriff (PDF)

Characterization of the neutron detector upgrade to the GP-SANS and Bio-SANS instruments at HFIR

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 2012-11, Vol.693, p.179-185

2012

Volltextzugriff (PDF)

Detection and photothermal actuation of microcantilever oscillations in air and liquid using a modified DVD optical pickup

Sensors and actuators. A. Physical., 2016-09, Vol.248, p.6-9

2016

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Cosmetic Breast Surgery

1, 2020

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Response of Soybean Cultivars to Bean pod mottle virus Infection

Plant disease, 2007-06, Vol.91 (6), p.719-726

2007

Volltextzugriff (PDF)

Efficacy of different fixation devices in maintaining an initial reduction for surgically managed distal radius fractures

Canadian Journal of Surgery, 2009-10, Vol.52 (5), p.E161-E166

2009

Volltextzugriff (PDF)

Cosmetic Breast Surgery

Volltextzugriff (PDF)

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors

Species differences in distribution and prediction of human V(ss) from preclinical data

An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes

Esterase activities in the blood, liver and intestine of several preclinical species and humans

Long-acting [kappa] opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Prediction of V(ss) from in vitro tissue-binding studies

Leaders in Sales and Sales Management

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Comparison of Methods of Initial Ascertainment in 58 Cases of Propionic Acidemia Enrolled in the Inborn Errors of Metabolism Information System Reveals Significant Differences in Time to Evaluation and Symptoms at Presentation

Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

Measuring Pediatric Hospital Readmission Rates to Drive Quality Improvement

Delays in melanoma presentation during the COVID-19 pandemic: A nationwide multi-institutional cohort study

Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments

Decomposition of monazite concentrate in sulphuric acid

Major features and forcing of high-latitude northern hemisphere atmospheric circulation using a 110,000-year-long glaciochemical series

Characterization of the neutron detector upgrade to the GP-SANS and Bio-SANS instruments at HFIR

Detection and photothermal actuation of microcantilever oscillations in air and liquid using a modified DVD optical pickup

Cosmetic Breast Surgery

Response of Soybean Cultivars to Bean pod mottle virus Infection

Efficacy of different fixation devices in maintaining an initial reduction for surgically managed distal radius fractures

Cosmetic Breast Surgery

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