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LRRK2 activation in idiopathic Parkinson's disease

Science translational medicine, 2018-07, Vol.10 (451)

2018

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α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

Science translational medicine, 2016-06, Vol.8 (342), p.342ra78

2016

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LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Neurobiology of disease, 2020-02, Vol.134, p.104626-104626, Article 104626

2020

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Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Nature chemical biology, 2021-04, Vol.17 (4), p.465-476

2021

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shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model

The Journal of clinical investigation, 2015-07, Vol.125 (7), p.2721-2735

2015

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Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

Neurobiology of disease, 2016-07, Vol.91, p.247-261

2016

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Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

Neurobiology of disease, 2009-06, Vol.34 (3), p.487-500

2009

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α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Redox biology, 2020-10, Vol.37, p.101695-101695, Article 101695

2020

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Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade

The Journal of neuroscience, 2011-01, Vol.31 (1), p.247-261

2011

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Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity

Experimental neurology, 2004-05, Vol.187 (1), p.47-57

2004

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Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: Implications for Parkinson disease

Neurobiology of disease, 2008-03, Vol.29 (3), p.477-489

2008

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Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

NPJ Parkinson's Disease, 2023-08, Vol.9 (1), p.121-121, Article 121

2023

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Could a loss of α‐synuclein function put dopaminergic neurons at risk?

Journal of neurochemistry, 2004-06, Vol.89 (6), p.1318-1324

2004

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Leptin Protects against 6-Hydroxydopamine-induced Dopaminergic Cell Death via Mitogen-activated Protein Kinase Signaling

The Journal of biological chemistry, 2007-11, Vol.282 (47), p.34479-34491

2007

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Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease

NPJ Parkinson's Disease, 2020-11, Vol.6 (1), p.34, Article 34

2020

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Alpha‐synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

Journal of neurochemistry, 2006-11, Vol.99 (4), p.1188-1196

2006

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Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine

Journal of neurochemistry, 2008-07, Vol.106 (1), p.333-346

2008

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comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

Journal of neurochemistry, 2007-09, Vol.102 (6), p.2118-2131

2007

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Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease

Biochemical pharmacology, 2005-11, Vol.70 (9), p.1371-1381

2005

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Cytotoxic and genotoxic potential of dopamine

Journal of neuroscience research, 1999-03, Vol.55 (6), p.659-665

1999

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Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

Journal of neurochemistry, 1995-02, Vol.64 (2), p.919-924

Hastings, Teresa G.

1995

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A comparison of Zn2+ - and Ca2+ -triggered depolarization of liver mitochondria reveals no evidence of Zn2+ -induced permeability transition

Cell calcium (Edinburgh), 2009-05, Vol.45 (5), p.447-455

2009

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Peroxynitrite‐ and Nitrite‐Induced Oxidation of Dopamine : Implications for Nitric Oxide in Dopaminergic Cell Loss

Journal of neurochemistry, 1999-12, Vol.73 (6), p.2546-2554

1999

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The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells

Antioxidants & redox signaling, 2005-05, Vol.7 (5-6), p.630-638

2005

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Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria : Implications for Parkinson's disease

Journal of neurochemistry, 1999-09, Vol.73 (3), p.1127-1137

1999

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LRRK2 activation in idiopathic Parkinson's disease

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model

Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade

Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity

Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: Implications for Parkinson disease

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

Could a loss of α‐synuclein function put dopaminergic neurons at risk?

Leptin Protects against 6-Hydroxydopamine-induced Dopaminergic Cell Death via Mitogen-activated Protein Kinase Signaling

Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease

Alpha‐synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine

comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease

Cytotoxic and genotoxic potential of dopamine

Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

A comparison of Zn2+ - and Ca2+ -triggered depolarization of liver mitochondria reveals no evidence of Zn2+ -induced permeability transition

Peroxynitrite‐ and Nitrite‐Induced Oxidation of Dopamine : Implications for Nitric Oxide in Dopaminergic Cell Loss

The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells

Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria : Implications for Parkinson's disease

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