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Advanced glycation end products in the pathogenesis of chronic kidney disease

Kidney international, 2018-04, Vol.93 (4), p.803-813

2018

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The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy

Diabetes (New York, N.Y.), 2014-01, Vol.63 (1), p.50-52

2014

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Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine

Redox biology, 2021-06, Vol.42, p.101920-101920, Article 101920

2021

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Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors

International journal of molecular sciences, 2022-02, Vol.23 (5), p.2453

2022

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Dicarbonyl Intermediates in the Maillard Reaction

Annals of the New York Academy of Sciences, 2005-06, Vol.1043 (1), p.111-117

THORNALLEY, PAUL J.

2005

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Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

Diabetes (New York, N.Y.), 2016-08, Vol.65 (8), p.2282-2294

2016

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Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation

Nutrients, 2021-07, Vol.13 (7), p.2374

2021

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Protein Glycation in Plants-An Under-Researched Field with Much Still to Discover

International journal of molecular sciences, 2020-05, Vol.21 (11), p.3942

2020

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Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications

Frontiers in endocrinology (Lausanne), 2024-01, Vol.14, p.1268308-1268308

2024

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Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (22), p.E4472-E4481

2017

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Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease

International journal of molecular sciences, 2022-12, Vol.24 (1), p.152

2022

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Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

Diabetes (New York, N.Y.), 2008-10, Vol.57 (10), p.2809-2817

2008

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Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes

Diabetes (New York, N.Y.), 2015-01, Vol.64 (1), p.9-11

2015

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Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response

Redox biology, 2024-02, Vol.69, p.103025-103025, Article 103025

2024

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Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts

International journal of molecular sciences, 2017-02, Vol.18 (3), p.480-480

2017

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Peptide Mapping Identifies Hotspot Site of Modification in Human Serum Albumin by Methylglyoxal Involved in Ligand Binding and Esterase Activity

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5724-5732

2005

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Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes

PloS one, 2012-12, Vol.7 (12), p.e53175

2012

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Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

Diabetes (New York, N.Y.), 2009-12, Vol.58 (12), p.2893-2903

2009

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Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Diabetes (New York, N.Y.), 2003-08, Vol.52 (8), p.2110-2120

2003

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Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

Diabetes (New York, N.Y.), 2006-07, Vol.55 (7), p.1961-1969

2006

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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

Frontiers in oncology, 2021-11, Vol.11, p.748698-748698

2021

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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Redox biology, 2023-02, Vol.59, p.102574-102574, Article 102574

2023

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High Glucose Increases Angiopoietin-2 Transcription in Microvascular Endothelial Cells through Methylglyoxal Modification of mSin3A

The Journal of biological chemistry, 2007-10, Vol.282 (42), p.31038-31045

2007

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Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke

International journal of molecular sciences, 2022-03, Vol.23 (6), p.3387

2022

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High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

Scientific reports, 2020-07, Vol.10 (1), p.12709-12709, Article 12709

2020

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Advanced glycation end products in the pathogenesis of chronic kidney disease

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy

Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine

Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors

Dicarbonyl Intermediates in the Maillard Reaction

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation

Protein Glycation in Plants-An Under-Researched Field with Much Still to Discover

Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease

Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes

Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response

Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts

Peptide Mapping Identifies Hotspot Site of Modification in Human Serum Albumin by Methylglyoxal Involved in Ligand Binding and Esterase Activity

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

High Glucose Increases Angiopoietin-2 Transcription in Microvascular Endothelial Cells through Methylglyoxal Modification of mSin3A

Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke

High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

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