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Should OA research focus on “mice” or “men”?

Osteoarthritis and cartilage, 2015-04, Vol.23, p.A22-A22

Little, C.B

2015

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New guidelines on publishing animal studies

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S6-S6

Little, C.B

2012

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Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: “DEPART well-prepared and ARRIVE safely”

Osteoarthritis and cartilage, 2017-03, Vol.25 (3), p.354-363

2017

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Getting value out of preclinical models: translation and prediction

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S1-S1

2016

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Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib)

Bone (New York, N.Y.), 2014-02, Vol.59, p.151-161

2014

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Models of injury and osteoarthritis: the role of impact severity and joint instability

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S410-S410

2016

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Zonal differences in meniscus matrix turnover and cytokine response

Osteoarthritis and cartilage, 2012-01, Vol.20 (1), p.49-59

2012

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Evidence for articular cartilage regeneration in MRL/MpJ mice

Osteoarthritis and cartilage, 2008-11, Vol.16 (11), p.1319-1326

2008

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Acute loading injuries and their relation to post-traumatic osteoarthritis in a preclinical model

Osteoarthritis and cartilage, 2015-04, Vol.23, p.A281-A281

2015

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The effects of intra-articular injection of mesenchymal stem cells versus hyaluronan hexadecylamide-derivative on post-traumatic OA: the relationship between synovial inflammation, structural pathology and pain sensitisation

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S324-S325

2016

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Comprehensive expression analysis of candidate MIRNAS in osteoarthritic joint tissues from a mouse model of post-traumatic OA

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S347-S347

2016

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MicroRNA expression profiling of articular cartilage from a mouse model of post-traumatic OA

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S345-S346

2016

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003 STRESS-DEPRIVATION UNCOUPLES METALLOPROTEINASE AND INHIBITOR EXPRESSION AND REDUCES MATERIAL PROPERTIES OF DISTINCT TENDON REGIONS

Osteoarthritis and cartilage, 2009, Vol.17, p.S10-S10

2009

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1-11 CARTILAGE BIOLOGY IN OSTEOARTHRITIS: ACTIVATION OF MATRIX DEGRADING ENZYMES

Osteoarthritis and cartilage, 2011-09, Vol.19, p.S4-S4

2011

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Short but not long term sclerostin inhibition worsens post-traumatic osteoarthritis in mice

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S337-S338

2014

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Sclerostin regulation of WISP1 and MMPS in chondrocytes is dependent on the LRP5/6 binding domain but not secretion from the cell

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S55-S55

2013

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Protease activated receptor-2 (PAR-2), but not PAR-1, modulates synovial macrophage maturation in post-traumatic osteoarthritis

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S61-S61

2013

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Establishing a method for measuring primary knee hyperalgesia in the murine DMM model of osteoarthritis

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S419-S420

2014

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Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S28-S29

2014

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Depletion of perlecan domain I heparan sulfate regulates fibroblast growth factor activity in cartilage and protects against cartilage loss and osteophyte development in post-traumatic osteoarthritis

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S49-S49

2012

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Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S30-S30

2012

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506 HYMOVIS™, A HEXADECYLAMIDE HYALURONAN DERIVATIVE (HYADD®4-G), INHIBITS GENE EXPRESSION CHANGES INDUCED BY INTERLEUKIN-lp IN CHONDROCYTES AND SYNOVIAL FIBROBLASTS DERIVED FROM OSTEOARTHRHIS PATIENTS

Osteoarthritis and cartilage, 2011-09, Vol.19, p.S234-S234

2011

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Post-traumatic osteoarthritis is accompanied by a distinct pattern of synovial inflammatory cell infiltration

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S60-S61

2013

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Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S12-S12

2014

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Distinct pain mechanisms in two different models of arthritis

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S252-S253

2012

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Should OA research focus on “mice” or “men”?

New guidelines on publishing animal studies

Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: “DEPART well-prepared and ARRIVE safely”

Getting value out of preclinical models: translation and prediction

Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib)

Models of injury and osteoarthritis: the role of impact severity and joint instability

Zonal differences in meniscus matrix turnover and cytokine response

Evidence for articular cartilage regeneration in MRL/MpJ mice

Acute loading injuries and their relation to post-traumatic osteoarthritis in a preclinical model

The effects of intra-articular injection of mesenchymal stem cells versus hyaluronan hexadecylamide-derivative on post-traumatic OA: the relationship between synovial inflammation, structural pathology and pain sensitisation

Comprehensive expression analysis of candidate MIRNAS in osteoarthritic joint tissues from a mouse model of post-traumatic OA

MicroRNA expression profiling of articular cartilage from a mouse model of post-traumatic OA

003 STRESS-DEPRIVATION UNCOUPLES METALLOPROTEINASE AND INHIBITOR EXPRESSION AND REDUCES MATERIAL PROPERTIES OF DISTINCT TENDON REGIONS

1-11 CARTILAGE BIOLOGY IN OSTEOARTHRITIS: ACTIVATION OF MATRIX DEGRADING ENZYMES

Short but not long term sclerostin inhibition worsens post-traumatic osteoarthritis in mice

Sclerostin regulation of WISP1 and MMPS in chondrocytes is dependent on the LRP5/6 binding domain but not secretion from the cell

Protease activated receptor-2 (PAR-2), but not PAR-1, modulates synovial macrophage maturation in post-traumatic osteoarthritis

Establishing a method for measuring primary knee hyperalgesia in the murine DMM model of osteoarthritis

Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep

Depletion of perlecan domain I heparan sulfate regulates fibroblast growth factor activity in cartilage and protects against cartilage loss and osteophyte development in post-traumatic osteoarthritis

Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo

506 HYMOVIS™, A HEXADECYLAMIDE HYALURONAN DERIVATIVE (HYADD®4-G), INHIBITS GENE EXPRESSION CHANGES INDUCED BY INTERLEUKIN-lp IN CHONDROCYTES AND SYNOVIAL FIBROBLASTS DERIVED FROM OSTEOARTHRHIS PATIENTS

Post-traumatic osteoarthritis is accompanied by a distinct pattern of synovial inflammatory cell infiltration

Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors

Distinct pain mechanisms in two different models of arthritis

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