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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Nature (London), 2010-03, Vol.464 (7287), p.431-435

2010

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Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Cells (Basel, Switzerland), 2020-01, Vol.9 (1), p.198

2020

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Nature (London), 2010-03, Vol.464 (7287), p.427-430

2010

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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Cell, 2013-08, Vol.154 (5), p.1036-1046

2013

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Regulation of RAF protein kinases in ERK signalling

Nature reviews. Molecular cell biology, 2015-05, Vol.16 (5), p.281-298

2015

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Arabidopsis Raf‐like kinases act as positive regulators of subclass III SnRK2 in osmostress signaling

The Plant journal : for cell and molecular biology, 2020-07, Vol.103 (2), p.634-644

2020

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Structural basis for the action of the drug trametinib at KSR-bound MEK

Nature (London), 2020-12, Vol.588 (7838), p.509-514

2020

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A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants

Nature communications, 2020-01, Vol.11 (1), p.613-613, Article 613

2020

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RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Nature cell biology, 2018-09, Vol.20 (9), p.1064-1073

2018

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer

Cell cycle (Georgetown, Tex.), 2015-08, Vol.14 (15), p.2473-2483

2015

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PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

European journal of medicinal chemistry, 2016-02, Vol.109, p.314-341

2016

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A lactate-induced response to hypoxia

Cell, 2015-04, Vol.161 (3), p.595-609

2015

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Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Expert opinion on therapeutic targets, 2012-01, Vol.16 (1), p.103-119

2012

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Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

Nature structural & molecular biology, 2022-10, Vol.29 (10), p.966-977

2022

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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

The Journal of clinical investigation, 2013-01, Vol.123 (1), p.340-347

2013

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Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (46), p.E6388-E6396

2015

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Inhibition of RAF dimers: it takes two to tango

Biochemical Society transactions, 2021-02, Vol.49 (1), p.237-251

2021

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Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Molecular cell, 2023-04, Vol.83 (8), p.1210-1215

2023

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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Nature communications, 2019-06, Vol.10 (1), p.2532-16, Article 2532

2019

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Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

The Journal of clinical investigation, 2013-05, Vol.123 (5), p.2155-2168

2013

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Current Development Status of MEK Inhibitors

Molecules (Basel, Switzerland), 2017-09, Vol.22 (10), p.1551

2017

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Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants

Nature communications, 2020-12, Vol.11 (1), p.6184-6184, Article 6184

2020

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A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

Cancer discovery, 2022-04, Vol.12 (4), p.899-912

2022

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Regulation of RAF protein kinases in ERK signalling

Arabidopsis Raf‐like kinases act as positive regulators of subclass III SnRK2 in osmostress signaling

Structural basis for the action of the drug trametinib at KSR-bound MEK

A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

A lactate-induced response to hypoxia

Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2

Inhibition of RAF dimers: it takes two to tango

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Current Development Status of MEK Inhibitors

Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants

A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

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