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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Nature cell biology, 2020-04, Vol.22 (4), p.389-400

2020

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Efficacy of MEK inhibition in patients with histiocytic neoplasms

Nature (London), 2019-03, Vol.567 (7749), p.521-524

2019

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Nature genetics, 2012-02, Vol.44 (2), p.133-139

2012

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IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes

Journal of cellular physiology, 2020-05, Vol.235 (5), p.4466-4480

2020

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VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17

BMC biology, 2024-10, Vol.22 (1), p.222-24, Article 222

2024

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MEK1/2 dual-specificity protein kinases: Structure and regulation

Biochemical and biophysical research communications, 2012-01, Vol.417 (1), p.5-10

Roskoski, Robert

2012

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Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

Circulation (New York, N.Y.), 2019-07, Vol.140 (3), p.207-224

2019

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Pharmacoproteomic characterisation of human colon and rectal cancer

Molecular systems biology, 2017-11, Vol.13 (11), p.951-n/a

2017

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ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

Biochemical and biophysical research communications, 2018-06, Vol.500 (4), p.873-878

2018

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The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

The Journal of biological chemistry, 2017-05, Vol.292 (21), p.8750-8761

2017

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Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

Science signaling, 2011-03, Vol.4 (166), p.ra17

2011

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MAPK kinase 10.2 promotes disease resistance and drought tolerance by activating different MAPKs in rice

The Plant journal : for cell and molecular biology, 2017-11, Vol.92 (4), p.557-570

2017

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RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation

Plant physiology (Bethesda), 2020-05, Vol.183 (1), p.331-344

2020

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Direct Phosphorylation and Regulation of Poly(ADP-Ribose) Polymerase-1 by Extracellular Signal-Regulated Kinases 1/2

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.7136-7141

2006

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Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3569-3580

2016

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Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation

PloS one, 2014-09, Vol.9 (9), p.e106725-e106725

2014

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Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

The Journal of biological chemistry, 2014-12, Vol.289 (49), p.34366-34377

2014

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Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

The Journal of biological chemistry, 2013-11, Vol.288 (47), p.33966-33977

2013

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MEK Is a Key Regulator of Gliogenesis in the Developing Brain

Neuron (Cambridge, Mass.), 2012-09, Vol.75 (6), p.1035-1050

2012

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Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues

Molecular and cellular endocrinology, 2015-03, Vol.403, p.64-77

2015

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Germline Mutations in Genes within the MAPK Pathway Cause Cardio-Facio-Cutaneous Syndrome

Science (American Association for the Advancement of Science), 2006-03, Vol.311 (5765), p.1287-1290

2006

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Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells

Advanced science, 2021-05, Vol.8 (10), p.2004344-n/a

2021

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Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells

Cell biology and toxicology, 2014-12, Vol.30 (6), p.345-360

2014

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Dissection of Kinase Isoforms through Orthogonal and Chemical Inducible Signaling Cascades

Chembiochem : a European journal of chemical biology, 2017-08, Vol.18 (16), p.1593-1598

2017

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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Efficacy of MEK inhibition in patients with histiocytic neoplasms

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes

VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

MEK1/2 dual-specificity protein kinases: Structure and regulation

Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

Pharmacoproteomic characterisation of human colon and rectal cancer

ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

MAPK kinase 10.2 promotes disease resistance and drought tolerance by activating different MAPKs in rice

RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation

Direct Phosphorylation and Regulation of Poly(ADP-Ribose) Polymerase-1 by Extracellular Signal-Regulated Kinases 1/2

Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation

Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation

Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

MEK Is a Key Regulator of Gliogenesis in the Developing Brain

Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues

Germline Mutations in Genes within the MAPK Pathway Cause Cardio-Facio-Cutaneous Syndrome

Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells

Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells

Dissection of Kinase Isoforms through Orthogonal and Chemical Inducible Signaling Cascades

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