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Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons

Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.446-457

1999

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Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

Drug development research, 1995-02, Vol.34 (2), p.91-109

1995

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Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Molecular pharmacology, 1998-07, Vol.54 (1), p.50-58

1998

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Antitumor 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone derivatives : Interactions with tubulin

Biochemical pharmacology, 1996-01, Vol.51 (1), p.53-59

1996

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Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

Science (American Association for the Advancement of Science), 1992-10, Vol.258 (5081), p.447-451

1992

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Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

Journal of medicinal chemistry, 1993-04, Vol.36 (9), p.1146-1156

1993

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Mining and Visualizing Large Anticancer Drug Discovery Databases

Journal of Chemical Information and Computer Sciences, 2000-03, Vol.40 (2), p.367-379

2000

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Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity

Molecular pharmacology, 1998-02, Vol.53 (2), p.241-251

1998

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Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues

Journal of Chemical Information and Computer Sciences, 1998-03, Vol.38 (2), p.189-199

1998

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Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program

Biochemical pharmacology, 1995-03, Vol.49 (7), p.947-954

1995

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Design and Synthesis of Ellipticinium Salts and 1,2-Dihydroellipticines with High Selectivities against Human CNS Cancers in vitro

Journal of medicinal chemistry, 1994-07, Vol.37 (14), p.2190-2197

1994

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Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

JNCI : Journal of the National Cancer Institute, 1996-03, Vol.88 (5), p.259-269

1996

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15882-15889

1991

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Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

Biochemical and biophysical research communications, 1992-08, Vol.186 (3), p.1600-1606

1992

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An Information-Intensive Approach to the Molecular Pharmacology of Cancer

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5298), p.343-349

1997

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A protein expression database for the molecular pharmacology of cancer

Electrophoresis, 1997, Vol.18 (3-4), p.647-653

1997

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In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1752-1756

1987

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Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent

Biochemical pharmacology, 1993-06, Vol.45 (12), p.2449-2456

1993

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Reduced folate carrier gene (RFC1) expression and anti‐folate resistance in transfected and non‐selected cell lines

International journal of cancer, 1997-07, Vol.72 (1), p.184-190

1997

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Azatoxin derivatives with potent and selective action on topoisomerase II

Biochemical pharmacology, 1995-05, Vol.49 (9), p.1283-1290

1995

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Experimental antileukemic agents. Coralyne, analogs, and related compounds

Journal of medicinal chemistry, 1974-03, Vol.17 (3), p.347-351

1974

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Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin

Biochemical pharmacology, 1994-10, Vol.48 (7), p.1413-1419

1994

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Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines

Nature medicine, 1997-04, Vol.3 (4), p.395-401

1997

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In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance

Cancer chemotherapy and pharmacology, 1993, Vol.31 (5), p.401-406

1993

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Response

JNCI : Journal of the National Cancer Institute, 1996-08, Vol.88 (16), p.1161

1996

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Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons

Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Antitumor 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone derivatives : Interactions with tubulin

Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

Mining and Visualizing Large Anticancer Drug Discovery Databases

Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity

Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues

Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program

Design and Synthesis of Ellipticinium Salts and 1,2-Dihydroellipticines with High Selectivities against Human CNS Cancers in vitro

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

A protein expression database for the molecular pharmacology of cancer

In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models

Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent

Reduced folate carrier gene (RFC1) expression and anti‐folate resistance in transfected and non‐selected cell lines

Azatoxin derivatives with potent and selective action on topoisomerase II

Experimental antileukemic agents. Coralyne, analogs, and related compounds

Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin

Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines

In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance

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