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Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA

Organic & biomolecular chemistry, 2017, Vol.15 (15), p.3265-3275

2017

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Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

Nucleic acids research, 2020-11, Vol.48 (19), p.10998-11015

2020

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The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

Molecular cell, 2015-02, Vol.57 (3), p.445-455

2015

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Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

Scientific reports, 2015-07, Vol.5 (1), p.12531-12531, Article 12531

2015

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Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

Biochemical and biophysical research communications, 2015-10, Vol.466 (2), p.192-195

2015

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Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

Diabetologia, 2021-09, Vol.64 (9), p.2077-2091

2021

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G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

Journal of the American Chemical Society, 2024-03, Vol.146 (10), p.6926-6935

2024

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Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

PloS one, 2015, Vol.10 (10), p.e0140194-e0140194

2015

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Pregnancy to Postpartum Transition of Serum Metabolites in Women with Gestational Diabetes

Metabolism, clinical and experimental, 2017-07, Vol.72, p.27-36

2017

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Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

PloS one, 2017-09, Vol.12 (9), p.e0184117

2017

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Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet

Metabolites, 2021, Vol.11 (7), p.440

2021

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Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation

Organic letters, 2015-12, Vol.17 (24), p.6194-6197

2015

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The liver-alpha-cell axis during weight loss in type 2 diabetes

Diabetologia, 2018, Vol.61, p.S97

2018

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Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

Cell chemical biology, 2016-03, Vol.23 (3), p.404-414

2016

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Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNAElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob00300e

2017-04

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Plasma metabolomic response to postmenopausal weight loss induced by different diets

Metabolomics, 2016-05, Vol.12 (5), p.1, Article 85

2016

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Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

NPJ Parkinson's Disease, 2015-01, Vol.1 (1), p.15024-15024, Article 15024

2015

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Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Aβ-peptide aggregation inhibitors

Organic & biomolecular chemistry, 2005-01, Vol.3 (15), p.2817

2005

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The effect of side chain variations on quinazoline-pyrimidine G-quadruplex DNA ligands

European journal of medicinal chemistry, 2023-02, Vol.248, p.115103, Article 115103

2023

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Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli

mBio, 2014-10, Vol.5 (6), p.e02038

2014

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Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G‑Quadruplex Stabilization

Journal of the American Chemical Society, 2020-02, Vol.142 (6), p.2876-2888

2020

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Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (21), p.10510-10517

2019

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A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis

mBio, 2014-12, Vol.6 (1), p.e02304-e02314

2014

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Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones

Chemistry & biology, 2013-10, Vol.20 (10), p.1245-1254

2013

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Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

Pregnancy to Postpartum Transition of Serum Metabolites in Women with Gestational Diabetes

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet

Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation

The liver-alpha-cell axis during weight loss in type 2 diabetes

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNAElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob00300e

Plasma metabolomic response to postmenopausal weight loss induced by different diets

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Aβ-peptide aggregation inhibitors

The effect of side chain variations on quinazoline-pyrimidine G-quadruplex DNA ligands

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G‑Quadruplex Stabilization

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis

Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones

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