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Nutritional Signaling via Free Fatty Acid Receptors

International Journal of Molecular Sciences, 2016-03, Vol.17 (4), p.450-450

2016

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In silico and in vitro screening for potential anticancer candidates targeting GPR120

Bioorganic & medicinal chemistry letters, 2021-01, Vol.31, p.127672, Article 127672

2021

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Immunomodulatory Activity of Docosahexenoic Acid on RAW264.7 Cells Activation through GPR120-Mediated Signaling Pathway

Journal of agricultural and food chemistry, 2018-01, Vol.66 (4), p.926-934

2018

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Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device

Sensors (Basel, Switzerland), 2019-04, Vol.19 (7), p.1663

2019

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Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5748

2021

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Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Bioorganic & medicinal chemistry letters, 2014-07, Vol.24 (14), p.3100-3103

2014

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Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15), p.2599-2604

2018

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Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

International journal of molecular sciences, 2024-06, Vol.25 (11), p.5866

2024

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Effects of Edible Oils with Different n‑6/n‑3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway

Journal of agricultural and food chemistry, 2020-11, Vol.68 (45), p.12641-12650

2020

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Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

Bioorganic chemistry, 2021-03, Vol.108, p.104657, Article 104657

2021

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Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7072

2023

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GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

International journal of molecular sciences, 2021-10, Vol.22 (19), p.10544

2021

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Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Molecules (Basel, Switzerland), 2021-11, Vol.26 (22), p.6907

2021

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Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists

Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (24), p.127650-127650, Article 127650

2020

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Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120

Frontiers in chemistry, 2022-01, Vol.10, p.816014-816014

2022

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Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

International journal of molecular sciences, 2019-05, Vol.20 (11), p.2625

2019

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Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption

International journal of molecular sciences, 2023-12, Vol.24 (23), p.17000

2023

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Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy

Acta pharmacologica Sinica, 2021-02, Vol.42 (2), p.252-263

2021

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Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus

Molecules (Basel, Switzerland), 2022-12, Vol.27 (24), p.9018

2022

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N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5476

2024

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Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression

Acta pharmacologica Sinica, 2017-02, Vol.38 (2), p.192-200

2017

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Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Chemistry & biodiversity, 2023-01, Vol.20 (1), p.e202200814-n/a

2023

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Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.841-846

2018

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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1278-1283

2017

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Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3272-3278

2017

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Nutritional Signaling via Free Fatty Acid Receptors

In silico and in vitro screening for potential anticancer candidates targeting GPR120

Immunomodulatory Activity of Docosahexenoic Acid on RAW264.7 Cells Activation through GPR120-Mediated Signaling Pathway

Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device

Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design

Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

Effects of Edible Oils with Different n‑6/n‑3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway

Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists

Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120

Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy

Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus

N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells

Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression

Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

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