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Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

Frontiers in pharmacology, 2019-09, Vol.10, p.1047-1047

2019

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Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

International journal of molecular sciences, 2018-12, Vol.20 (1), p.79

2018

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Hsp90 activator Aha1 drives production of pathological tau aggregates

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (36), p.9707-9712

2017

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4158-4169

2013

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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Nature communications, 2018-10, Vol.9 (1), p.4532-13, Article 4532

2018

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Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature communications, 2020-11, Vol.11 (1), p.6046-6046, Article 6046

2020

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Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency

PloS one, 2014-09, Vol.9 (9), p.e107241-e107241

2014

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Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Scientific reports, 2023-01, Vol.13 (1), p.317-317, Article 317

2023

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Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

International journal of molecular sciences, 2019-06, Vol.20 (11), p.2738

2019

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Human cyclophilin 40 unravels neurotoxic amyloids

PLoS biology, 2017-06, Vol.15 (6), p.e2001336

2017

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Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

The Journal of clinical investigation, 2021-02, Vol.131 (4), p.1-22

2021

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Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice

Scientific reports, 2022-05, Vol.12 (1), p.7372-7372, Article 7372

2022

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Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain

International journal of molecular sciences, 2022-01, Vol.23 (2), p.851

2022

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Imbalance of Hsp70 family variants fosters tau accumulation

The FASEB journal, 2013-04, Vol.27 (4), p.1450-1459

2013

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Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

PloS one, 2012-04, Vol.7 (4), p.e35566

2012

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SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.217-229

2022

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Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

Scientific reports, 2017-12, Vol.7 (1), p.17951-9, Article 17951

2017

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Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5442

2020

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Heparan Sulfate Proteoglycans in Tauopathy

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (12), p.1792

2022

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Dynamic Aha1 co‐chaperone binding to human Hsp90

Protein science, 2019-09, Vol.28 (9), p.1545-1551

2019

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Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

Cells (Basel, Switzerland), 2020-01, Vol.9 (1), p.210

2020

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Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

The Journal of biological chemistry, 2010-01, Vol.285 (4), p.2498-2505

2010

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Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice

Acta neuropathologica communications, 2021-05, Vol.9 (1), p.85-85, Article 85

2021

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The multiple facets of the Hsp90 machine

Nature structural & molecular biology, 2019-02, Vol.26 (2), p.92-95

2019

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Genetically engineered mouse models of FK506-binding protein 5

Journal of cellular biochemistry, 2023-02

2023

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Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

Hsp90 activator Aha1 drives production of pathological tau aggregates

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency

Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Human cyclophilin 40 unravels neurotoxic amyloids

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice

Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain

Imbalance of Hsp70 family variants fosters tau accumulation

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

Heparan Sulfate Proteoglycans in Tauopathy

Dynamic Aha1 co‐chaperone binding to human Hsp90

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice

The multiple facets of the Hsp90 machine

Genetically engineered mouse models of FK506-binding protein 5

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