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Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening

Neuropharmacology, 2020-05, Vol.167, p.107750-107750, Article 107750

2020

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Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Cold Spring Harbor perspectives in medicine, 2015-08, Vol.5 (8), p.a022863

2015

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Key factors in the discovery and development of new antiepileptic drugs

Nature reviews. Drug discovery, 2010-01, Vol.9 (1), p.68-82

2010

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Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor

Epilepsia (Copenhagen), 2022-06, Vol.63 (6), p.1580-1590

2022

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Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models

Epilepsia (Copenhagen), 2019-02, Vol.60 (2), p.303-314

2019

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Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

Epilepsia (Copenhagen), 2018-10, Vol.59 (10), p.1811-1841

2018

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Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control

Neurochemistry international, 2012-09, Vol.61 (4), p.546-558

2012

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Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

Cells (Basel, Switzerland), 2023-04, Vol.12 (9), p.1233

2023

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Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy

Journal of neuropathology and experimental neurology, 2016-04, Vol.75 (4), p.366-378

2016

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Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy

Journal of translational medicine, 2023-09, Vol.21 (1), p.1-642, Article 642

2023

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A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome

PLoS genetics, 2009-09, Vol.5 (9), p.e1000649

2009

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Issues related to development of new antiseizure treatments

Epilepsia (Copenhagen), 2013-08, Vol.54 (s4), p.24-34

2013

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Community Pharmacist-Centered training program improves confidence in delivering epilepsy care

Epilepsy & behavior, 2024-09, Vol.158, p.109933, Article 109933

2024

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Development and pharmacologic characterization of the rat 6 Hz model of partial seizures

Epilepsia (Copenhagen), 2017-06, Vol.58 (6), p.1073-1084

2017

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Stakeholder perceptions of community pharmacist population health management of people living with epilepsy

Epilepsy & behavior, 2021-12, Vol.125, p.108389-108389, Article 108389

2021

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Brief history of anti‐seizure drug development

Epilepsia open, 2018-12, Vol.3 (Suppl Suppl 2), p.114-119

2018

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Preclinical Development of Antiepileptic Drugs: Past, Present, and Future Directions

Epilepsia (Copenhagen), 2003-09, Vol.44 (s7), p.2-8

White, H. Steve

2003

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Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

The Journal of physiology, 2008-07, Vol.586 (14), p.3405-3423

2008

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Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy

Journal of translational medicine, 2023-11, Vol.21 (1), p.1-796, Article 796

2023

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Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?

Epilepsia (Copenhagen), 2020-11, Vol.61 (11), p.2329-2339

2020

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The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

Epilepsia (Copenhagen), 2017-06, Vol.58 (6), p.1054-1062

2017

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Mechanisms of Action of Antiepileptic Drugs

International Review of Neurobiology, 2007, Vol.81 (2), p.85-110

2007

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Interleukin-6, Produced by Resident Cells of the Central Nervous System and Infiltrating Cells, Contributes to the Development of Seizures following Viral Infection

Journal of Virology, 2011-07, Vol.85 (14), p.6913-6922

2011

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Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.318-329

2015

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Drug resistance in epilepsy

Lancet neurology, 2023-08, Vol.22 (8), p.723-734

2023

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Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Key factors in the discovery and development of new antiepileptic drugs

Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control

Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy

Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy

A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome

Issues related to development of new antiseizure treatments

Community Pharmacist-Centered training program improves confidence in delivering epilepsy care

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures

Stakeholder perceptions of community pharmacist population health management of people living with epilepsy

Brief history of anti‐seizure drug development

Preclinical Development of Antiepileptic Drugs: Past, Present, and Future Directions

Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy

Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?

The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

Mechanisms of Action of Antiepileptic Drugs

Interleukin-6, Produced by Resident Cells of the Central Nervous System and Infiltrating Cells, Contributes to the Development of Seizures following Viral Infection

Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model

Drug resistance in epilepsy

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