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Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria

Materials & design, 2018-02, Vol.140, p.332-344

2018

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A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

Nature medicine, 2002-10, Vol.8 (10), p.1171-1174

2002

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An IPTG Inducible Conditional Expression System for Mycobacteria

PloS one, 2015-08, Vol.10 (8), p.e0134562-e0134562

2015

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Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Nature immunology, 2003-10, Vol.4 (10), p.949-955

2003

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Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates

Vaccine, 2009-07, Vol.27 (34), p.4709-4717

2009

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Insulin Tregopil: An Ultra-Fast Oral Recombinant Human Insulin Analog: Preclinical and Clinical Development in Diabetes Mellitus

Drugs (New York, N.Y.), 2023-09, Vol.83 (13), p.1161-1178

2023

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Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

Infection and Immunity, 2005-02, Vol.73 (2), p.1196-1203

2005

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Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

Infection and Immunity, 2004-05, Vol.72 (5), p.3031-3037

2004

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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

ACS chemical biology, 2014-10, Vol.9 (10), p.2274-2282

2014

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Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8533-8542

2013

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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Nature communications, 2015-03, Vol.6 (1), p.6715-6715, Article 6715

2015

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Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

ACS medicinal chemistry letters, 2019-10, Vol.10 (10), p.1480-1485

2019

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Mycobacterium tuberculosis Δ RD1 Δ panCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis

Vaccine, 2006-09, Vol.24 (37), p.6309-6320

2006

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Benzimidazoles: Novel Mycobacterial Gyrase Inhibitors from Scaffold Morphing

ACS medicinal chemistry letters, 2014-07, Vol.5 (7), p.820-825

2014

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Discriminatory Power of Three Typing Techniques in Determining Relatedness of Nosocomial Klebsiella pneumoniae Isolates from a Tertiary Hospital in India

Indian journal of medical microbiology, 2017-07, Vol.35 (3), p.361-368

2017

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Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5702-5713

2014

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Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

Microbes and infection, 2005-05, Vol.7 (5), p.955-961

2005

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Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding

ACS medicinal chemistry letters, 2015-07, Vol.6 (7), p.741-746

2015

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Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

Immunology, 2007-02, Vol.120 (2), p.192-206

2007

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Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis

Immunology Letters, 2006-03, Vol.103 (2), p.196-199

2006

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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

MedChemComm, 2016, Vol.7 (5), p.1022-1032

2016

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Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis: e0147188

PloS one, 2016-01, Vol.11 (1)

2016

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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathwayThe authors declare no competing interests.Electronic supplementary information (ESI) available: Materials and methods, synthesis Schemes 1A and B, Fig. S1: 3D flexible superimposition of compounds 3h, 8d and 17a with bedaquiline, Fig. S2 and S3: 2D binding site interaction of inhibitors - bedaquiline, compounds 3h, 8d, 12 and 17a - at the ATPase binding site and

2016-05

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Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

An IPTG Inducible Conditional Expression System for Mycobacteria

Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates

Insulin Tregopil: An Ultra-Fast Oral Recombinant Human Insulin Analog: Preclinical and Clinical Development in Diabetes Mellitus

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

Mycobacterium tuberculosis Δ RD1 Δ panCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis

Benzimidazoles: Novel Mycobacterial Gyrase Inhibitors from Scaffold Morphing

Discriminatory Power of Three Typing Techniques in Determining Relatedness of Nosocomial Klebsiella pneumoniae Isolates from a Tertiary Hospital in India

N‑Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding

Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis

Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis

Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis: e0147188

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