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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Cancer research (Chicago, Ill.), 2019-01, Vol.79 (1), p.251-262

2019

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Mechanisms of transcriptional regulation by p53

Cell death and differentiation, 2018-01, Vol.25 (1), p.133-143

2018

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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Nature communications, 2021-02, Vol.12 (1), p.986-11, Article 986

2021

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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

Nature (London), 2016-10, Vol.538 (7623), p.118-122

2016

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Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

Cell death and differentiation, 2017-02, Vol.24 (2), p.357-370

2017

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Drugging the p53 pathway: understanding the route to clinical efficacy

Nature reviews. Drug discovery, 2014-03, Vol.13 (3), p.217-236

2014

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Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

The Journal of biological chemistry, 2016-03, Vol.291 (13), p.6714-6722

2016

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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

Molecular cell, 2016-10, Vol.64 (1), p.51-64

2016

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PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins

Nucleic acids research, 2021-01, Vol.49 (D1), p.D404-D411

2021

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Discoveries and controversies in BCL‐2 protein‐mediated apoptosis

The FEBS journal, 2016-07, Vol.283 (14), p.2690-2700

2016

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p53 β-hydroxybutyrylation attenuates p53 activity

Cell death & disease, 2019-03, Vol.10 (3), p.243, Article 243

2019

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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.E11302-E11310

2018

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Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer

The Journal of biological chemistry, 2012-08, Vol.287 (33), p.28152-28162

2012

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The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

Nucleic acids research, 2018-01, Vol.46 (2), p.804-822

2018

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Prion-like aggregation of mutant p53 in cancer

Trends in biochemical sciences (Amsterdam. Regular ed.), 2014-06, Vol.39 (6), p.260-267

2014

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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1038-1052

2015

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Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Chemical reviews, 2023-07, Vol.123 (14), p.9094-9138

2023

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In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

Journal of the American Chemical Society, 2013-08, Vol.135 (31), p.11623-11633

2013

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Allele-Specific p53 Mutant Reactivation

Cancer cell, 2012-05, Vol.21 (5), p.614-625

2012

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Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S-Phase and Promotes Viral Replication

Journal of virology, 2021-07, Vol.95 (16), p.e0018721-e0018721

2021

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Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells

The Journal of biological chemistry, 2019-06, Vol.294 (24), p.9430-9439

2019

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Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications

Accounts of chemical research, 2020-10, Vol.53 (10), p.2425-2442

2020

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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (17), p.8390-8396

2019

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p53 is regulated by the lysine demethylase LSD1

Nature, 2007-09, Vol.449 (7158), p.105-108

2007

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Acetylation Is Indispensable for p53 Activation

Cell, 2008-05, Vol.133 (4), p.612-626

2008

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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Mechanisms of transcriptional regulation by p53

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

Drugging the p53 pathway: understanding the route to clinical efficacy

Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins

Discoveries and controversies in BCL‐2 protein‐mediated apoptosis

p53 β-hydroxybutyrylation attenuates p53 activity

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

Prion-like aggregation of mutant p53 in cancer

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

Allele-Specific p53 Mutant Reactivation

Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S-Phase and Promotes Viral Replication

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells

Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

p53 is regulated by the lysine demethylase LSD1

Acetylation Is Indispensable for p53 Activation

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