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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity

Journal of molecular biology, 2024-06, Vol.436 (12), p.168608, Article 168608

2024

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Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

Cell, 2016-08, Vol.166 (5), p.1163-1175.e12

2016

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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

FEBS letters, 2009-06, Vol.583 (12), p.1817-1824

2009

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The biology of IQGAP proteins: beyond the cytoskeleton

EMBO reports, 2015-04, Vol.16 (4), p.427-446

2015

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Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4472-4484

2018

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11381-11386

2011

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SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6686), p.eadk1291

2024

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RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

The Journal of cell biology, 2013-09, Vol.202 (6), p.917-935

2013

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Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

Cell, 2012-11, Vol.151 (4), p.709-723

2012

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Comparative Proteomic Analysis of Exosomes and Microvesicles in Human Saliva for Lung Cancer

Journal of proteome research, 2018-03, Vol.17 (3), p.1101-1107

2018

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SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

Neuron (Cambridge, Mass.), 2024-09, Vol.112 (18), p.3058-3068.e8

2024

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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

eLife, 2020-06, Vol.9

2020

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Tau exacerbates excitotoxic brain damage in an animal model of stroke

Nature communications, 2017-09, Vol.8 (1), p.473-15, Article 473

2017

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Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

European journal of medicinal chemistry, 2023-02, Vol.248, p.115104, Article 115104

2023

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CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Cell death & disease, 2019-11, Vol.10 (12), p.900-14, Article 900

2019

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Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Human molecular genetics, 2015-07, Vol.24 (14), p.4006-4023

2015

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The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor

Cancer cell, 2013-09, Vol.24 (3), p.365-378

2013

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Sar1 GTPase Activity Is Regulated by Membrane Curvature

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1014-1027

2016

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Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Cancer research (Chicago, Ill.), 2017-08, Vol.77 (16), p.4328-4341

2017

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A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

Proceedings of the National Academy of Sciences - PNAS, 2020-05, Vol.117 (21), p.11432-11443

2020

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Journal of cell biology, 2024-09, Vol.223 (9)

2024

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The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

Current biology, 2010-09, Vol.20 (18), p.1654-1659

2010

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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing

Neuron (Cambridge, Mass.), 2023-05, Vol.111 (10), p.1637-1650.e5

2023

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Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

Structure (London), 2020-03, Vol.28 (3), p.290-300.e4

2020

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

The biology of IQGAP proteins: beyond the cytoskeleton

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

Comparative Proteomic Analysis of Exosomes and Microvesicles in Human Saliva for Lung Cancer

SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor

Sar1 GTPase Activity Is Regulated by Membrane Curvature

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing

Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

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