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Structural Simplification of Natural Products

Chemical reviews, 2019-03, Vol.119 (6), p.4180-4220

2019

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Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

Angewandte Chemie International Edition, 2021-10, Vol.60 (43), p.23299-23305

International ed. in English, 2021

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State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors

Chemical Society reviews, 2015-11, Vol.44 (22), p.8238-8259

2015

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New lead structures in antifungal drug discovery

Current medicinal chemistry, 2011-02, Vol.18 (5), p.733-766

2011

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Targeting necroptosis in anticancer therapy: mechanisms and modulators

Acta pharmaceutica Sinica. B, 2020-09, Vol.10 (9), p.1601-1618

2020

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Structural simplification: an efficient strategy in lead optimization

Acta pharmaceutica Sinica. B, 2019-09, Vol.9 (5), p.880-901

2019

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New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7593-7613

2012

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Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

Acta pharmaceutica Sinica. B, 2020-07, Vol.10 (7), p.1294-1308

2020

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NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

Acta pharmaceutica Sinica. B, 2022-06, Vol.12 (6), p.2859-2868

2022

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Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans

Frontiers in microbiology, 2021-05, Vol.12, p.680382-680382

2021

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Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Acta pharmaceutica Sinica. B, 2021-06, Vol.11 (6), p.1617-1628

2021

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Small molecules for combating multidrug-resistant superbug Candida auris infections

Acta pharmaceutica Sinica. B, 2022-11, Vol.12 (11), p.4056-4074

2022

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Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery

ACS medicinal chemistry letters, 2018-01, Vol.9 (1), p.34-38

2018

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One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

Organic letters, 2018-04, Vol.20 (7), p.1712-1715

2018

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Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review

Current medicinal chemistry, 2014, Vol.21 (16), p.1861-1870

2014

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Corrigendum: Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans

Frontiers in microbiology, 2021-10, Vol.12, p.773140-773140

2021

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One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp 3 )-H activations

Chemical communications (Cambridge, England), 2017, Vol.53 (9), p.1534-1537

2017

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Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Acta pharmaceutica Sinica. B, 2019-01, Vol.9 (1), p.144-156

2019

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Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy

Advanced science, 2024-07, Vol.11 (25), p.e2401623-n/a

2024

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Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2656-2674

2022

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Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

Acta pharmaceutica Sinica. B, 2022-09, Vol.12 (9), p.3650-3666

2022

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PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders

Journal of advanced research, 2024-09, Vol.63, p.219-230

2024

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New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors

Current medicinal chemistry, 2011-10, Vol.18 (28), p.4389-4409

2011

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Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Acta pharmaceutica Sinica. B, 2023-07, Vol.13 (7), p.3080-3092

2023

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Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5268-5277

2017

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Structural Simplification of Natural Products

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors

New lead structures in antifungal drug discovery

Targeting necroptosis in anticancer therapy: mechanisms and modulators

Structural simplification: an efficient strategy in lead optimization

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Small molecules for combating multidrug-resistant superbug Candida auris infections

Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review

Corrigendum: Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp 3 )-H activations

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis

Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders

New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors

Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

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