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Diversity-Oriented Synthesis through Rh-Catalyzed Selective Transformations of a Novel Multirole Directing Group

ChemCatChem, 2015-09, Vol.7 (18), p.2986-2990

2015

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γ-secretase inhibitors for the treatment of Alzheimer's disease

Drug development research, 2009-03, Vol.70 (2), p.94-100

2009

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Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5550-5553

2007

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Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors

Bioorganic & medicinal chemistry letters, 2022-01, Vol.56, p.128463-128463, Article 128463

2022

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Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8806-8817

2015

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SAR of tricyclic sulfones as γ-secretase inhibitors

Science China. Chemistry, 2011-11, Vol.54 (11), p.1688-1701

2011

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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.498-501

2016

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (21), p.5534-5545

2016

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Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5836-5841

2016

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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Tetrahedron, 2016-10, Vol.72 (40), p.6011-6020

2016

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Total Syntheses of (+)-Himbacine and (+)-Himbeline

Journal of the American Chemical Society, 1995-09, Vol.117 (36), p.9369-9370

1995

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Applications of Organosulfur Chemistry to Organic Synthesis: Total Synthesis of (+)-Himbeline and (+)-Himbacine

Journal of organic chemistry, 1997-07, Vol.62 (15), p.5023-5033

1997

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A straightforward synthetic approach to the spiroketal-enol ethers synthesis of natural antifeeding compound tonghaosu and its analogs

Tetrahedron, 1998-10, Vol.54 (41), p.12523-12538

1998

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Dopamine D1/D5 Receptor Antagonists with Improved Pharmacokinetics: Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of Benzazepine D1/D5 Antagonists

Journal of medicinal chemistry, 2005-02, Vol.48 (3), p.680-693

2005

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Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1575-1578

2012

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7223-7226

2012

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A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.850-853

2013

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Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2591-2596

2010

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Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure–activity relationship studies

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3645-3648

2010

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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.892-896

2012

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Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3674-3678

2006

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Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3668-3673

2006

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Abstract 1286: AGX87 - An IND-stage potent and selective next-generation NTRK/ROS1 inhibitor of WT and clinical resistant mutants with superiority over tyrosine kinase inhibitors currently approved or in development

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1286-1286

2021

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Abstract 1145: AGX323 - A SAM-competitive, orally available inhibitor of protein arginine methyltransferase 5 (PRMT5) with potent cellular antiproliferative and in vivo antitumor activity against selected solid cancer types

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1145-1145

2021

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Diversity-Oriented Synthesis through Rh-Catalyzed Selective Transformations of a Novel Multirole Directing Group

γ-secretase inhibitors for the treatment of Alzheimer's disease

Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors

Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors

SAR of tricyclic sulfones as γ-secretase inhibitors

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Total Syntheses of (+)-Himbacine and (+)-Himbeline

Applications of Organosulfur Chemistry to Organic Synthesis: Total Synthesis of (+)-Himbeline and (+)-Himbacine

A straightforward synthetic approach to the spiroketal-enol ethers synthesis of natural antifeeding compound tonghaosu and its analogs

Dopamine D1/D5 Receptor Antagonists with Improved Pharmacokinetics: Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of Benzazepine D1/D5 Antagonists

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure–activity relationship studies

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Abstract 1286: AGX87 - An IND-stage potent and selective next-generation NTRK/ROS1 inhibitor of WT and clinical resistant mutants with superiority over tyrosine kinase inhibitors currently approved or in development

Abstract 1145: AGX323 - A SAM-competitive, orally available inhibitor of protein arginine methyltransferase 5 (PRMT5) with potent cellular antiproliferative and in vivo antitumor activity against selected solid cancer types

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