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Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

Pharmacology & therapeutics (Oxford), 2020-06, Vol.210, p.107518, Article 107518

2020

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Clinical Candidates Targeting the ATR-CHK1-WEE1 Axis in Cancer

Cancers, 2021-02, Vol.13 (4), p.795

2021

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Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Molecular cell, 2020-02, Vol.77 (3), p.528-541.e8

2020

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Excessive reactive oxygen species induce transcription-dependent replication stress

Nature communications, 2023-03, Vol.14 (1), p.1791-1791, Article 1791

2023

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The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress

Nucleic acids research, 2023-03, Vol.51 (5), p.2298-2318

2023

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RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

Genes, 2020-02, Vol.11 (2), p.232

2020

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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment

Molecules (Basel, Switzerland), 2015-12, Vol.20 (12), p.22084-22101

2015

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From pyridinium-based to centrally active acetylcholinesterase reactivators

Mini reviews in medicinal chemistry, 2014-01, Vol.14 (3), p.215-221

2014

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Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy

Current cancer drug targets, 2016-03, Vol.16 (3), p.200-208

2016

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The development of ataxia telangiectasia mutated kinase inhibitors

Mini reviews in medicinal chemistry, 2014-10, Vol.14 (10), p.805-1

2014

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DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells

Nucleic acids research, 2022-11, Vol.50 (21), p.12274-12290

2022

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Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8985-9003

2015

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Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation

Nucleic acids research, 2024-08

2024

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2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1

European journal of medicinal chemistry, 2023-10, Vol.258, p.115611-115611, Article 115611

2023

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7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

European journal of medicinal chemistry, 2014-07, Vol.82, p.426-438

2014

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7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties

European journal of medicinal chemistry, 2022-10, Vol.240, p.114580-114580, Article 114580

2022

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IN SILICO LIBRARY SCREENING TO FIND NOVEL ANTICANCER AGENT WITH CHEMOSENSITIZING PROPERTIES: FOCUS ON TARGETING ATAXIA TELANGIECTASIA AND Rad3 RELATED KINASE

Military Medical Science Letters, 2024-03, Vol.93 (1), p.68-83

2024

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Abstract 1411: Utilizing 7-azaindoles, 2,7-diazaindoles, and 1 H -pyrazoles as core structures for novel cancer chemosensitizers

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.1411-1411

2022

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MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

Science advances, 2024-02, Vol.10 (6), p.eadk2685-eadk2685

2024

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Novel caffeine derivatives with antiproliferative activity

RSC advances, 2016, Vol.6 (39), p.32534-32539

2016

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Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity

Future medicinal chemistry, 2018-09, Vol.10 (17), p.2029-2038

2018

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Re-covered, Coordinated, e-volved: Editor's Annual Report—Volume 49, 2010

Journal of the American Academy of Child and Adolescent Psychiatry, 2010-12, Vol.49 (12), p.1288-1289

Martin, Andrés, M.D., M.P.H

2010

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Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis

Journal of the American Academy of Child and Adolescent Psychiatry, 2011-01, Vol.50 (1), p.63-72

2011

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Novel caffeine derivatives with antiproliferative activityElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra22889a

2016-04

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Pediatric Psycho-oncology: Psychosocial Aspects and Clinical Interventions

2nd Edition, 2012

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Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

Clinical Candidates Targeting the ATR-CHK1-WEE1 Axis in Cancer

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Excessive reactive oxygen species induce transcription-dependent replication stress

The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment

From pyridinium-based to centrally active acetylcholinesterase reactivators

Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy

The development of ataxia telangiectasia mutated kinase inhibitors

DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1

7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties

IN SILICO LIBRARY SCREENING TO FIND NOVEL ANTICANCER AGENT WITH CHEMOSENSITIZING PROPERTIES: FOCUS ON TARGETING ATAXIA TELANGIECTASIA AND Rad3 RELATED KINASE

Abstract 1411: Utilizing 7-azaindoles, 2,7-diazaindoles, and 1 H -pyrazoles as core structures for novel cancer chemosensitizers

MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

Novel caffeine derivatives with antiproliferative activity

Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity

Re-covered, Coordinated, e-volved: Editor's Annual Report—Volume 49, 2010

Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis

Novel caffeine derivatives with antiproliferative activityElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra22889a

Pediatric Psycho-oncology: Psychosocial Aspects and Clinical Interventions

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