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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Advanced drug delivery reviews, 2001-10, Vol.50, p.S41-S67

2001

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Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.305-315

2019

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

The AAPS journal, 2008, Vol.10 (1), p.213-226

2008

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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The AAPS journal, 2009-06, Vol.11 (2), p.323-334

2009

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The AAPS journal, 2021-06, Vol.23 (4), p.89-89, Article 89

2021

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In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Pharmaceutical research, 2006-08, Vol.23 (8), p.1712-1720

2006

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The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.268-278

2019

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Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Journal of chemical education, 2020-08, Vol.97 (8), p.2212-2220

2020

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

The AAPS journal, 2019-07, Vol.21 (4), p.65, Article 65

2019

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.821-830

2018

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.610-625

2017

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.831-839

2018

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.626-642

2017

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Modeling of absorption

Methods in molecular biology (Clifton, N.J.), 2012, Vol.929, p.313

2012

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Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

Journal of pharmaceutical sciences, 1998-11, Vol.87 (11), p.1286-1291

1998

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Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

Biochemical and biophysical research communications, 1998-09, Vol.250 (1), p.103-107

1998

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The composite solubility versus pH profile and its role in intestinal absorption prediction

AAPS PharmSci, 2003-01, Vol.5 (1), p.E4-49

2003

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Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Investigative ophthalmology & visual science, 1998-11, Vol.39 (12), p.2365-2373

1998

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[2] Computer modeling of combining site structure of anti-hapten monoclonal antibodies

Methods in Enzymology, 1991, Vol.203, p.21-45

1991

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Modeling of absorption

Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

The composite solubility versus pH profile and its role in intestinal absorption prediction

Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

[2] Computer modeling of combining site structure of anti-hapten monoclonal antibodies

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