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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Pharmaceutics, 2024-01, Vol.16 (1), p.96

2024

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Pharmaceutics, 2021-08, Vol.13 (9), p.1325

2021

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Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

The AAPS journal, 2008, Vol.10 (1), p.213-226

2008

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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The AAPS journal, 2009-06, Vol.11 (2), p.323-334

2009

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The AAPS journal, 2021-06, Vol.23 (4), p.89-89, Article 89

2021

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A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

European journal of pharmaceutical sciences, 2020-12, Vol.155, p.105552-105552, Article 105552

2020

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The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1808-1818

2016

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

The AAPS journal, 2019-07, Vol.21 (4), p.65, Article 65

2019

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.610-625

2017

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.626-642

2017

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.598-609

2017

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Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603

Protein engineering, design and selection, 1992, Vol.5 (3), p.215-228

1992

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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

The Journal of pharmacology and experimental therapeutics, 1997-03, Vol.280 (3), p.1284

1997

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The composite solubility versus pH profile and its role in intestinal absorption prediction

AAPS PharmSci, 2003-01, Vol.5 (1), p.E4-49

2003

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Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Investigative ophthalmology & visual science, 1998-11, Vol.39 (12), p.2365-2373

1998

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Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

Journal of neurochemistry, 1991-11, Vol.57 (5), p.1818-1821

1991

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Cyber Patient™: A Multimedia Pharmacokinetic Simulation Program for Case Study Generation in a Problem-Solving Curriculum

American journal of pharmaceutical education, 1995, Vol.59 (4), p.409-416

Bolger, Michael B.

1995

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Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

The Journal of pharmacology and experimental therapeutics, 1996-02, Vol.276 (2), p.667

1996

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Use of Comfuter-Based Case Studies in a Problem-Solving Curriculum

American journal of pharmaceutical education, 1997, Vol.61 (1), p.97-102

1997

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PharmLab™: A Computer Program for the Calculation and Visualization of Drug Degradation pH Rate Profiles

American journal of pharmaceutical education, 1997, Vol.61 (3), p.281-287

1997

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Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C

AAPS PharmSci, 2001-01, Vol.3 (2), p.E16-90

2001

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Differential Responses of Expressed Recombinant Human γ‐Aminobutyric Acid A Receptors to Neurosteroids

Journal of neurochemistry, 1991-11, Vol.57 (5), p.1818-1821

1991

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PBPK models for the prediction of in vivo performance of oral dosage forms

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

The composite solubility versus pH profile and its role in intestinal absorption prediction

Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

Cyber Patient™: A Multimedia Pharmacokinetic Simulation Program for Case Study Generation in a Problem-Solving Curriculum

Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

Use of Comfuter-Based Case Studies in a Problem-Solving Curriculum

PharmLab™: A Computer Program for the Calculation and Visualization of Drug Degradation pH Rate Profiles

Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C

Differential Responses of Expressed Recombinant Human γ‐Aminobutyric Acid A Receptors to Neurosteroids

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