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Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

European journal of nuclear medicine and molecular imaging, 2019-09, Vol.46 (10), p.2178-2189

2019

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Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

PloS one, 2013-08, Vol.8 (8), p.e72301-e72301

2013

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (23), p.9810-9815

2007

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Engineering amyloid-like assemblies from unstructured peptides via site-specific lipid conjugation

PloS one, 2014-09, Vol.9 (9), p.e105641

2014

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Synthesis of Components for the Generation of Constitutional Dynamic Analogues of Nucleic Acids

Helvetica chimica acta, 2008-01, Vol.91 (1), p.1-20

2008

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Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1405-1411

2017

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Sequence-independent Control of Peptide Conformation in Liposomal Vaccines for Targeting Protein Misfolding Diseases

The Journal of biological chemistry, 2011-04, Vol.286 (16), p.13966-13976

2011

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Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

Angewandte Chemie (International ed.), 2013-10, Vol.52 (41), p.10905-10908

International ed. in English, 2013

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Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

Journal of Alzheimer's disease, 2017-01, Vol.56 (2), p.585

2017

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TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell–independent isotype switch in mice

Blood, 2013-01, Vol.121 (1), p.85-94

2013

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DyNAs: Constitutional Dynamic Nucleic Acid Analogues

Chemistry : a European journal, 2006-11, Vol.12 (33), p.8581-8588

2006

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A liposomal anti-phospho-tau vaccine demonstrates higher immunogenicity and specificity than a classical peptide vaccine approach

Alzheimer's & dementia, 2013-07, Vol.9 (4), p.P326-P326

2013

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Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells

Cancer letters, 2007-11, Vol.257 (2), p.165-171

2007

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Phospho-tau–specific vaccine for the treatment of tau pathology

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P398-P399

2012

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Novel phospho-Tau specific monoclonal antibodies for the treatment of Tau-mediated pathology

Alzheimer's & dementia, 2011-07, Vol.7 (4), p.S480-S480

2011

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The safety profile of ACI-24, an oligo-specific amyloid beta vaccine, demonstrated decrease of large microbleedings in brain of aged Alzheimer's disease mouse model

Alzheimer's & dementia, 2009-07, Vol.5 (4), p.P425-P426

2009

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Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

Chemical communications (Cambridge, England), 2004-03 (5), p.516-517

2004

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Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)

Organic & biomolecular chemistry, 2003-10, Vol.1 (19), p.3277-3292

2003

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Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)This paper is dedicated to Professor Heinz G. Floss on the occasion of his 70th birthday.Electronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b3/b315768g

Chemical communications (Cambridge, England), 2004-02 (5), p.516

2004

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An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

PloS one, 2016-03, Vol.11 (3), p.e0152471-e0152471

2016

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Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)Electronic supplementary information (ESI) available: experimental details (16 Figures, 3 Tables). See http://www.rsc.org/suppdata/ob/b3/b306156f

Organic & biomolecular chemistry, 2003-09, Vol.1 (19), p.3277

2003

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Discovery and preclinical characterization of 18FPI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies

European journal of nuclear medicine and molecular imaging, 2019-09, Vol.46 (10), p.2178

2019

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Synthesis and nucleic-acid-binding properties of sulfamide- and 3 '-N-sulfamate-modified DNA

Perkin 1 : an international journal of organic and bio-organic chemistry, 2002-02 (4), p.485-495

2002

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A general route for the synthesis of triazacyclononane functionalised with one, two or three pendant phosphine arms: crystal structure of [Zn2L2Cl3][ClO4], L =N-(diphenylphosphinopropyl)-1,4,7-triazacyclononane

Chemical communications (Cambridge, England), 1996 (15), p.1817

1996

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Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Engineering amyloid-like assemblies from unstructured peptides via site-specific lipid conjugation

Synthesis of Components for the Generation of Constitutional Dynamic Analogues of Nucleic Acids

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer’s disease

Sequence-independent Control of Peptide Conformation in Liposomal Vaccines for Targeting Protein Misfolding Diseases

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell–independent isotype switch in mice

DyNAs: Constitutional Dynamic Nucleic Acid Analogues

A liposomal anti-phospho-tau vaccine demonstrates higher immunogenicity and specificity than a classical peptide vaccine approach

Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells

Phospho-tau–specific vaccine for the treatment of tau pathology

Novel phospho-Tau specific monoclonal antibodies for the treatment of Tau-mediated pathology

The safety profile of ACI-24, an oligo-specific amyloid beta vaccine, demonstrated decrease of large microbleedings in brain of aged Alzheimer's disease mouse model

Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)Electronic supplementary information (ESI) available: experimental details (16 Figures, 3 Tables). See http://www.rsc.org/suppdata/ob/b3/b306156f

Discovery and preclinical characterization of 18FPI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies

An Anti-[beta]-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

Synthesis and nucleic-acid-binding properties of sulfamide- and 3 '-N-sulfamate-modified DNA

A general route for the synthesis of triazacyclononane functionalised with one, two or three pendant phosphine arms: crystal structure of [Zn2L2Cl3][ClO4], L =N-(diphenylphosphinopropyl)-1,4,7-triazacyclononane

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