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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

FEBS letters, 2009-06, Vol.583 (12), p.1817-1824

2009

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The biology of IQGAP proteins: beyond the cytoskeleton

EMBO reports, 2015-04, Vol.16 (4), p.427-446

2015

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RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

The Journal of cell biology, 2013-09, Vol.202 (6), p.917-935

2013

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CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Cell death & disease, 2019-11, Vol.10 (12), p.900-14, Article 900

2019

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Tau exacerbates excitotoxic brain damage in an animal model of stroke

Nature communications, 2017-09, Vol.8 (1), p.473-15, Article 473

2017

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Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

European journal of medicinal chemistry, 2023-02, Vol.248, p.115104, Article 115104

2023

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Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Cell death and differentiation, 2017-01, Vol.24 (1), p.15-25

2017

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Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Human molecular genetics, 2015-07, Vol.24 (14), p.4006-4023

2015

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Sar1 GTPase Activity Is Regulated by Membrane Curvature

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1014-1027

2016

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Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Cancer research (Chicago, Ill.), 2017-08, Vol.77 (16), p.4328-4341

2017

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The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

Current biology, 2010-09, Vol.20 (18), p.1654-1659

2010

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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Scientific reports, 2019-06, Vol.9 (1), p.9126-15, Article 9126

2019

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Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3685-3699

2018

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Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

Structure (London), 2020-03, Vol.28 (3), p.290-300.e4

2020

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EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells

Cancer research (Chicago, Ill.), 2020-10, Vol.80 (20), p.4371-4385

2020

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DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation

Biochimica et biophysica acta. Molecular basis of disease, 2022-04, Vol.1868 (4), p.166353-166353, Article 166353

2022

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Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

Organic & biomolecular chemistry, 2019-05, Vol.17 (19), p.4879-4891

2019

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Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4822-4835

2020

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The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.3134-3147

2020

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Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme

The journal of physical chemistry. B, 2015-10, Vol.119 (40), p.12838-12845

2015

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Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions

Cold Spring Harbor perspectives in medicine, 2019-03, Vol.9 (3), p.a031500

2019

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P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

Biochimie, 2009-03, Vol.91 (3), p.320-328

2009

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The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

The Journal of cell biology, 2023-06, Vol.222 (6), p.1

2023

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Inhibition of polar actin assembly by astral microtubules is required for cytokinesis

Nature communications, 2021-04, Vol.12 (1), p.2409-2409, Article 2409

2021

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

The biology of IQGAP proteins: beyond the cytoskeleton

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Sar1 GTPase Activity Is Regulated by Membrane Curvature

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells

DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation

Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)

Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme

Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

Inhibition of polar actin assembly by astral microtubules is required for cytokinesis

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