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MAPK pathways in radiation responses

Oncogene, 2003-09, Vol.22 (37), p.5885-5896

2003

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Radiation-induced cell signaling: inside-out and outside-in

Molecular cancer therapeutics, 2007-03, Vol.6 (3), p.789-801

2007

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Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells

Molecular cancer therapeutics, 2010-08, Vol.9 (8), p.2220-2231

2010

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Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

Oncogene, 2003-02, Vol.22 (8), p.1164-1180

2003

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Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

Molecular pharmacology, 2009-08, Vol.76 (2), p.342-355

2009

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mda- 7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Cytokine & growth factor reviews, 2010-10, Vol.21 (5), p.381-391

2010

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Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells

Molecular pharmacology, 2010-11, Vol.78 (5), p.909-917

2010

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Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

Clinical cancer research, 2008-09, Vol.14 (17), p.5385-5399

2008

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Inhibition of vimentin or β1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

Molecular cancer therapeutics, 2009-03, Vol.8 (3), p.499-508

2009

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Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells

Cancer biology & therapy, 2012-05, Vol.13 (7), p.567-574

2012

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Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

Molecular pharmacology, 2008-09, Vol.74 (3), p.807-822

2008

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OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells

Molecular pharmacology, 2006-08, Vol.70 (2), p.589-603

2006

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PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

Autophagy, 2008-05, Vol.4 (4), p.513-515

2008

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Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

Hepatology (Baltimore, Md.), 2002-04, Vol.35 (4), p.779-789

2002

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MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

Anti-cancer drugs, 2010-09, Vol.21 (8), p.725-731

2010

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Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

Oncogene, 2001-05, Vol.20 (25), p.3266-3280

2001

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Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein

Oncogene, 2004-10, Vol.23 (46), p.7679-7690

2004

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17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species

Molecular cancer therapeutics, 2010-05, Vol.9 (5), p.1378-1395

2010

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Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Molecular cancer therapeutics, 2007-12, Vol.6 (12), p.3101-3112

2007

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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Molecular cancer therapeutics, 2005-02, Vol.4 (2), p.257-270

2005

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Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling

Molecular pharmacology, 2007-09, Vol.72 (3), p.704-714

2007

Volltextzugriff (PDF)

mda-7 (IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling

Cancer biology & therapy, 2003-07, Vol.2 (4), p.347-353

2003

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MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells

Cancer biology & therapy, 2004-08, Vol.3 (8), p.739-751

2004

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Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Molecular cancer therapeutics, 2008-03, Vol.7 (3), p.616-629

2008

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Searching for a cure: Gene therapy for glioblastoma

Cancer biology & therapy, 2008-09, Vol.7 (9), p.1335-1340

2008

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MAPK pathways in radiation responses

Radiation-induced cell signaling: inside-out and outside-in

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

mda- 7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

Inhibition of vimentin or β1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling

mda-7 (IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Searching for a cure: Gene therapy for glioblastoma

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