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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1855-1879

2014

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1729-1744

2005

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Evolution of the Synthetic Process to an Advanced GPR40 Agonist

Organic process research & development, 2024-01, Vol.28 (1), p.310-324

2024

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Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272

Organic process research & development, 2022-04, Vol.26 (4), p.1327-1335

2022

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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097

Journal of organic chemistry, 2017-10, Vol.82 (19), p.10376-10387

2017

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Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole

Journal of organic chemistry, 1997-08, Vol.62 (16), p.5627-5629

1997

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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2839-2844

1998

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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1483-1486

2004

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Synthesis of Losoxantrone Metabolites Isolated from Human Urine

Heterocycles, 1999-11, Vol.51 (11), p.2603

1999

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Synthesis of N-Butyl Side Chain Hydroxylated Metabolites of Roxifiban, a Platelet Glycoprotein IIb/IIIa Receptor Antagonist

Heterocycles, 2004-07, Vol.63 (7), p.1585

2004

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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4291-4317

2022

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An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

Synthetic communications, 1998-12, Vol.28 (24), p.4525-4530

1998

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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

Molecular pharmacology, 2000-01, Vol.57 (1), p.75

2000

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The synthesis and antitumor evaluation of unsymmetrical bis-imides

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (2), p.163-168

1997

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Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

Molecular pharmacology, 2000-01, Vol.57 (1), p.75

2000

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A New Synthesis of Aminomalononitrile Tosylate

Synthesis (Stuttgart), 1980-01, Vol.1980 (10), p.801-802

1980

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Activity of DMP 840, a New Bis-naphthalimide, on Primary Human Tumor Colony-Forming Units

JNCI : Journal of the National Cancer Institute, 1994-10, Vol.86 (19), p.1462-1465

1994

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Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.125-128

2003

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ChemInform Abstract: An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

ChemInform, 1999-03, Vol.30 (11), p.no-no

1999

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ChemInform Abstract: Synthesis of Losoxantrone Metabolites Isolated from Human Urine

ChemInform, 2000-03, Vol.31 (11), p.no-no

2000

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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Evolution of the Synthetic Process to an Advanced GPR40 Agonist

Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders

Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups

Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097

Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

Synthesis of Losoxantrone Metabolites Isolated from Human Urine

Synthesis of N-Butyl Side Chain Hydroxylated Metabolites of Roxifiban, a Platelet Glycoprotein IIb/IIIa Receptor Antagonist

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)

An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2‑f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

The synthesis and antitumor evaluation of unsymmetrical bis-imides

Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

A New Synthesis of Aminomalononitrile Tosylate

Activity of DMP 840, a New Bis-naphthalimide, on Primary Human Tumor Colony-Forming Units

Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands

ChemInform Abstract: An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

ChemInform Abstract: Synthesis of Losoxantrone Metabolites Isolated from Human Urine

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