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Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad

Scientific reports, 2024-02, Vol.14 (1), p.4518-4518, Article 4518

2024

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Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure

Scientific reports, 2021-06, Vol.11 (1), p.11449-11449, Article 11449

2021

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Radioprotective Effects of ON 01210.Na upon Oral Administration

JOURNAL OF RADIATION RESEARCH, 2012, Vol.53 (3), p.368-376

2012

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Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

Radiation oncology (London, England), 2012-01, Vol.7 (1), p.6-6, Article 6

2012

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Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

Hematological oncology, 2015-06, Vol.33 (2), p.57-66

2015

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Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice

Journal of radiation research, 2012-07, Vol.53 (4), p.526-536

2012

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Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

Cancer chemotherapy and pharmacology, 2009-12, Vol.65 (1), p.177-186

2009

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Abstract 4906: Effect of gender on the rodent pharmacokinetics of ON 123300, a dual inhibitor of ARK5 and CDK4/6, for the treatment of cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4906-4906

2018

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Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure

Journal of proteome research, 2023-04, Vol.22 (4), p.1116-1126

2023

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Evaluation of Underlying Cause of Genitourinary (GU) Adverse Events (AEs) in Patients with Myelodysplastic Syndromes upon Oral Administration of Rigosertib: Safety and Pharmacokinetic Analysis of Rigosertib across Three Clinical Trials

Blood, 2018-11, Vol.132 (Supplement 1), p.3106-3106

2018

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Amelioration of Rigosertib Treatment Related Genitourinary (GU) Adverse Events (AEs) in Patients with Myelodysplastic Syndromes: Implementation of Novel Dosing Regimen Derived through Pharmacokinetic Modeling in Phase 2 Study of Oral Rigosertib in Combination with Azacitidine

Blood, 2018-11, Vol.132 (Supplement 1), p.4379-4379

2018

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Abstract 2172: ON 123300, an orally administered novel CDK4/6 + ARK5 inhibitor, exhibits potent antitumor activity in vivo: comparative studies with Palbociclib

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2172-2172

2017

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Rigosertib in combination with azacitidine in patients with myelodysplastic syndromes or acute myeloid leukemia: Results of a phase 1 study

Leukemia research, 2020-07, Vol.94, p.106369-106369, Article 106369

2020

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Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats

European journal of drug metabolism and pharmacokinetics, 2019-08, Vol.44 (4), p.531-538

2019

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Determination of Degradation Kinetics and Effect of Anion Exchange Resin on Dissolution of Novel Anticancer Drug Rigosertib in Acidic Conditions

AAPS PharmSciTech, 2018, Vol.19 (1), p.93-100

2018

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Abstract LB-A21: Single-agent activity and favorable pharmaceutical properties of orally bioavailable next-generation CDK4/6 inhibitor, ON 123300

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.LB-A21-LB-A21

2015

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Abstract 4687: Rigosertib synergistically enhances the anticancer activity of Cisplatin in various preclinical models of upper gastrointestinal cancers

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4687-4687

2016

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Abstract 1649: Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1649-1649

2015

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Determination of intestinal permeability of rigosertib (ON 01910.Na, Estybon): correlation with systemic exposure

Journal of pharmacy and pharmacology, 2013-07, Vol.65 (7), p.960-969

2013

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Abstract 4537: Pharmacokinetics of PLK2 inhibitor GBO-006-1, developed as a novel first-in-class molecule to treat triple negative breast cancer

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4537-4537

2014

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Comprehensive Analysis of Safety: Rigosertib in 557 Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Blood, 2016-12, Vol.128 (22), p.2011-2011

2016

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Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na

Leukemia research, 2012-08, Vol.36 (8), p.982-989

2012

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Abstract 3534: Proposed pathway of disposition of ON 01910. Na, a novel clinical trial stage anti-cancer agent: Implicaton of Mrp2 in biliary excretion in the isolated perfused rat liver system

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3534-3534

2010

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Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure

Journal of pharmaceutical sciences, 2013-02, Vol.102 (2), p.732-740

2013

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Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad

Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure

Radioprotective Effects of ON 01210.Na upon Oral Administration

Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice

Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

Abstract 4906: Effect of gender on the rodent pharmacokinetics of ON 123300, a dual inhibitor of ARK5 and CDK4/6, for the treatment of cancer

Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure

Evaluation of Underlying Cause of Genitourinary (GU) Adverse Events (AEs) in Patients with Myelodysplastic Syndromes upon Oral Administration of Rigosertib: Safety and Pharmacokinetic Analysis of Rigosertib across Three Clinical Trials

Amelioration of Rigosertib Treatment Related Genitourinary (GU) Adverse Events (AEs) in Patients with Myelodysplastic Syndromes: Implementation of Novel Dosing Regimen Derived through Pharmacokinetic Modeling in Phase 2 Study of Oral Rigosertib in Combination with Azacitidine

Abstract 2172: ON 123300, an orally administered novel CDK4/6 + ARK5 inhibitor, exhibits potent antitumor activity in vivo: comparative studies with Palbociclib

Rigosertib in combination with azacitidine in patients with myelodysplastic syndromes or acute myeloid leukemia: Results of a phase 1 study

Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats

Determination of Degradation Kinetics and Effect of Anion Exchange Resin on Dissolution of Novel Anticancer Drug Rigosertib in Acidic Conditions

Abstract LB-A21: Single-agent activity and favorable pharmaceutical properties of orally bioavailable next-generation CDK4/6 inhibitor, ON 123300

Abstract 4687: Rigosertib synergistically enhances the anticancer activity of Cisplatin in various preclinical models of upper gastrointestinal cancers

Phase 2 Expansion Study of Oral Rigosertib Combined with Azacitidine (AZA) in Patients (Pts) with Higher-Risk (HR) Myelodysplastic Syndromes (MDS): Efficacy and Safety Results in HMA Treatment Naïve & Relapsed (Rel)/Refractory (Ref) Patients

Abstract 1649: Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent

Determination of intestinal permeability of rigosertib (ON 01910.Na, Estybon): correlation with systemic exposure

Abstract 4537: Pharmacokinetics of PLK2 inhibitor GBO-006-1, developed as a novel first-in-class molecule to treat triple negative breast cancer

Comprehensive Analysis of Safety: Rigosertib in 557 Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na

Abstract 3534: Proposed pathway of disposition of ON 01910. Na, a novel clinical trial stage anti-cancer agent: Implicaton of Mrp2 in biliary excretion in the isolated perfused rat liver system

Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure

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