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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy

Cancer research (Chicago, Ill.), 2008-07, Vol.68 (14), p.5878-5887

2008

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.7177-7182

2011

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

The Journal of cell biology, 2008-10, Vol.183 (1), p.101-116

2008

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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

PloS one, 2009-05, Vol.4 (5), p.e5717-e5717

2009

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Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab

Clinical cancer research, 2009-06, Vol.15 (12), p.4147-4156

2009

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Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular cancer therapeutics, 2015-01, Vol.14 (1), p.40-47

2015

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Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.919-927

2012

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Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease

Journal of the American Society of Nephrology, 2022-06, Vol.33 (6), p.1087-1104

2022

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The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers

Cancer discovery, 2024-07, Vol.14 (7), p.1190-1205

2024

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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5520-5541

2016

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Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

Journal of medicinal chemistry, 2015-06, Vol.58 (12), p.5121-5136

2015

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Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)

Oncogene, 1999-10, Vol.18 (42), p.5814-5820

1999

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Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

Molecular & cellular proteomics, 2013-08, Vol.12 (8), p.2070-2080

2013

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PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

The Journal of pathology, 2014-12, Vol.234 (4), p.502-513

2014

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Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3518-3524

2016

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Insights into a Single Rod-like Helix in Activated Radixin Required for Membrane−Cytoskeletal Cross-Linking

Biochemistry (Easton), 2003-10, Vol.42 (40), p.11634-11641

2003

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Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB

The Journal of immunology (1950), 1999-09, Vol.163 (6), p.2990-2998

1999

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Inducible BRAF Suppression Models for Melanoma Tumorigenesis

Methods in Enzymology, 2008, Vol.439, p.25-38

2008

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Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy

The Journal of pharmacology and experimental therapeutics, 2009-04, Vol.329 (1), p.360

2009

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

Nature (London), 2000-07, Vol.406 (6791), p.86-90

2000

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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions

Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease

The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Insights into a Single Rod-like Helix in Activated Radixin Required for Membrane−Cytoskeletal Cross-Linking

Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB

Inducible BRAF Suppression Models for Melanoma Tumorigenesis

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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