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GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?

British journal of pharmacology, 2012-03, Vol.165 (6), p.1613-1616

2012

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G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains

Handbook of experimental pharmacology, 2008 (186), p.167

2008

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Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells

Hormone and metabolic research, 2014-11, Vol.46 (12), p.854-862

2014

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The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells

The Journal of biological chemistry, 2004-05, Vol.279 (20), p.20858-20865

2004

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Protein kinase C isozymes and the regulation of diverse cell responses

American journal of physiology. Lung cellular and molecular physiology, 2000-09, Vol.279 (3), p.429-L438

2000

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Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling

Cellular and molecular neurobiology, 2003-06, Vol.23 (3), p.305-314

2003

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Inhibition of Apoptosis in Normal and Transformed Intestinal Epithelial Cells by cAMP through Induction of Inhibitor of Apoptosis Protein (IAP)-2

Proceedings of the National Academy of Sciences - PNAS, 2003-07, Vol.100 (15), p.8921-8926

2003

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Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

Annual review of pharmacology and toxicology, 2001-01, Vol.41 (1), p.593-624

2001

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Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

The Journal of biological chemistry, 2001-11, Vol.276 (45), p.42063-42069

2001

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Therapeutic Oligonucleotides: State of the Art

Annual review of pharmacology and toxicology, 2019-01, Vol.59 (1), p.605-630

2019

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The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.141-161

2016

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Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease

Translational psychiatry, 2021-01, Vol.11 (1), p.76-76, Article 76

2021

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Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

Biochemical Society transactions, 2005-11, Vol.33 (Pt 5), p.1131-1134

2005

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Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials

JAMA : the journal of the American Medical Association, 2005-10, Vol.294 (15), p.1934

2005

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Cellular Release of and Response to ATP as Key Determinants of the Set-Point of Signal Transduction Pathways

The Journal of biological chemistry, 2000-04, Vol.275 (16), p.11735-11739

2000

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Therapeutic Approaches to the Treatment of Tinnitus

Annual review of pharmacology and toxicology, 2019-01, Vol.59 (1), p.291-313

2019

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Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s)

The Journal of pharmacology and experimental therapeutics, 2000-08, Vol.294 (2), p.407

2000

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Increased Expression of Adenylylcyclase Type VI Proportionately Increases β -adrenergic Receptor-Stimulated Production of cAMP in Neonatal Rat Cardiac Myocytes

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (3), p.1038-1043

1998

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A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors

Journal of leukocyte biology, 2004-07, Vol.76 (1), p.245-253

2004

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Hypertonic Stress Increases T Cell Interleukin-2 Expression through a Mechanism That Involves ATP Release, P2 Receptor, and p38 MAPK Activation

The Journal of biological chemistry, 2003-02, Vol.278 (7), p.4590-4596

2003

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Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Annual review of pharmacology and toxicology, 2021-01, Vol.61 (1), p.225-245

2021

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CSF Biomarker and PIB-PET-Derived Beta-Amyloid Signature Predicts Metabolic, Gray Matter, and Cognitive Changes in Nondemented Subjects

Cerebral cortex (New York, N.Y. 1991), 2012-09, Vol.22 (9), p.1993-2004

2012

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Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease

Science advances, 2020-04, Vol.6 (16), p.eaaz2387-eaaz2387

2020

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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual review of pharmacology and toxicology, 2018-01, Vol.58 (1), p.65-82

2018

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Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Annual review of pharmacology and toxicology, 2019-01, Vol.59 (1), p.1-14

Orrenius, Sten

2019

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GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?

G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains

Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells

The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells

Protein kinase C isozymes and the regulation of diverse cell responses

Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling

Inhibition of Apoptosis in Normal and Transformed Intestinal Epithelial Cells by cAMP through Induction of Inhibitor of Apoptosis Protein (IAP)-2

Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

Therapeutic Oligonucleotides: State of the Art

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease

Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials

Cellular Release of and Response to ATP as Key Determinants of the Set-Point of Signal Transduction Pathways

Therapeutic Approaches to the Treatment of Tinnitus

Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s)

Increased Expression of Adenylylcyclase Type VI Proportionately Increases β -adrenergic Receptor-Stimulated Production of cAMP in Neonatal Rat Cardiac Myocytes

A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors

Hypertonic Stress Increases T Cell Interleukin-2 Expression through a Mechanism That Involves ATP Release, P2 Receptor, and p38 MAPK Activation

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

CSF Biomarker and PIB-PET-Derived Beta-Amyloid Signature Predicts Metabolic, Gray Matter, and Cognitive Changes in Nondemented Subjects

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Role of Cell Death in Toxicology: Does It Matter How Cells Die?

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