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Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

International journal of molecular sciences, 2022-07, Vol.23 (13), p.7074

2022

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Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Frontiers in pharmacology, 2020-08, Vol.11, p.1201-1201

2020

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Anti-fibrotic Potential of AT2 Receptor Agonists

Frontiers in pharmacology, 2017-08, Vol.8, p.564-564

2017

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In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism

Hypertension (Dallas, Tex. 1979), 2021-07, Vol.78 (1), p.HYPERTENSIONAHA12117164-137

2021

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Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Biomedicine & pharmacotherapy, 2023-09, Vol.165, p.115238-115238, Article 115238

2023

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Serelaxin inhibits the profibrotic TGF‐β1/IL‐1β axis by targeting TLR‐4 and the NLRP3 inflammasome in cardiac myofibroblasts

The FASEB journal, 2019-12, Vol.33 (12), p.14717-14733

2019

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AT2 receptors: functional relevance in cardiovascular disease

Pharmacology & therapeutics (Oxford), 2008-12, Vol.120 (3), p.292-316

2008

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Angiotensin AT 2 receptors: cardiovascular hope or hype?

British journal of pharmacology, 2009-02, Vol.140 (5), p.809-824

2009

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Simultaneous targeting of oxidative stress and fibrosis reverses cardiomyopathy‐induced ventricular remodelling and dysfunction

British journal of pharmacology, 2021-06, Vol.178 (12), p.2424-2442

2021

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Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE^(-/-) Mice

International Journal of Vascular Medicine, 2013-01, Vol.2013, p.915983-8

2013

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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

European journal of medicinal chemistry, 2024-02, Vol.265, p.116122-116122, Article 116122

2024

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Long-term dietary nitrate supplementation slows the progression of established atherosclerosis in ApoE−/− mice fed a high fat diet

European journal of nutrition, 2023-06, Vol.62 (4), p.1845-1857

2023

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A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice

Journal of vascular research, 2008-02, Vol.45 (2), p.143-152

2008

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N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Bioorganic & medicinal chemistry, 2021-01, Vol.29, p.115859-115859, Article 115859

2021

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A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Cardiovascular drugs and therapy, 2019-12, Vol.33 (6), p.687-692

2019

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Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil

ACS pharmacology & translational science, 2020-02, Vol.3 (1), p.76-87

2020

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Serelaxin and the AT 2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil

ACS pharmacology & translational science, 2020-02, Vol.3 (1), p.76-87

2020

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Abstract 016: Combined AT 2 Receptor Stimulation/ AT 1 Receptor Blockade Does Not Cause Renal Dysfunction

Hypertension (Dallas, Tex. 1979), 2017-09, Vol.70 (suppl_1)

2017

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Abstract 131: Insulin Regulated Aminopeptidase Inhibitors are More Effective Than the ACE Inhibitor, Perindopril in Preventing Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice

Hypertension (Dallas, Tex. 1979), 2019-09, Vol.74 (Suppl_1)

2019

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Angiotensin AT2 receptors: cardiovascular hope or hype?

British journal of pharmacology, 2003-11, Vol.140 (5), p.809-824

2003

Volltextzugriff (PDF)

Novel AT 2 R agonist, β-Pro 7 Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Biomedicine & pharmacotherapy, 2023-08, Vol.165, p.115238

2023

Volltextzugriff (PDF)

Anti-fibrotic Potential of AT 2 Receptor Agonists

Frontiers in pharmacology, 2017, Vol.8, p.564

2017

Volltextzugriff (PDF)

Differential regulation by AT 1 and AT 2 receptors of angiotensin II‐stimulated cyclic GMP production in rat uterine artery and aorta

British journal of pharmacology, 2009-01, Vol.141 (6), p.1024-1031

2009

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Chronic NaHS treatment is vasoprotective in high-fat-fed [ApoE.sup.-/-] mice

International journal of vascular medicine, 2013-01

2013

Volltextzugriff (PDF)

Differential regulation by AT(1) and AT(2) receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta

British journal of pharmacology, 2004-03, Vol.141 (6), p.1024

2004

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Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Anti-fibrotic Potential of AT2 Receptor Agonists

In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism

Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Serelaxin inhibits the profibrotic TGF‐β1/IL‐1β axis by targeting TLR‐4 and the NLRP3 inflammasome in cardiac myofibroblasts

AT2 receptors: functional relevance in cardiovascular disease

Angiotensin AT 2 receptors: cardiovascular hope or hype?

Simultaneous targeting of oxidative stress and fibrosis reverses cardiomyopathy‐induced ventricular remodelling and dysfunction

Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE^(-/-) Mice

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Long-term dietary nitrate supplementation slows the progression of established atherosclerosis in ApoE−/− mice fed a high fat diet

A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil

Serelaxin and the AT 2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil

Abstract 016: Combined AT 2 Receptor Stimulation/ AT 1 Receptor Blockade Does Not Cause Renal Dysfunction

Abstract 131: Insulin Regulated Aminopeptidase Inhibitors are More Effective Than the ACE Inhibitor, Perindopril in Preventing Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice

Angiotensin AT2 receptors: cardiovascular hope or hype?

Novel AT 2 R agonist, β-Pro 7 Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Anti-fibrotic Potential of AT 2 Receptor Agonists

Differential regulation by AT 1 and AT 2 receptors of angiotensin II‐stimulated cyclic GMP production in rat uterine artery and aorta

Chronic NaHS treatment is vasoprotective in high-fat-fed [ApoE.sup.-/-] mice

Differential regulation by AT(1) and AT(2) receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta

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