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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

Molecular cancer therapeutics, 2007-08, Vol.6 (8), p.2209-2219

2007

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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Haematologica (Roma), 2021-07, Vol.106 (7), p.1979-1987

2021

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Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2264-2273

2010

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CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1

Analytical biochemistry, 2013-11, Vol.442 (1), p.104-106

2013

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments

MedChemComm, 2013-11, Vol.4 (11), p.1513

2013

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Pelvic congestion syndrome: Early clinical results after transcatheter ovarian vein embolization

Journal of vascular surgery, 1998-11, Vol.28 (5), p.862-868

1998

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Genomics and the search for novel biomarkers in toxicology

Biomarkers, 2003-03, Vol.8 (2), p.79-92

2003

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Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.11120-11137

2016

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Abstract LB-068: Development of a screening cascade to identify selective small molecule inhibitors of DNMT1

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-068-LB-068

2018

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Abstract B05: Discovery, validation and targeting of novel synthetic lethal interactions in academic drug discovery

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.B05-B05

2017

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Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2834-2844

2015

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Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Cellular and molecular life sciences : CMLS, 2016-02, Vol.73 (4), p.883-900

2016

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Abstract 2994: Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2994-2994

2018

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Abstract B98: Development and evaluation of selective, reversible LSD1 inhibitors from fragment startpoints

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B98-B98

2013

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h

2013-10

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Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

The Journal of immunology (1950), 2017-10, Vol.199 (8), p.2652-2667

2017

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Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3658-3676

2021

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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Blood, 2022-10, Vol.140 (17), p.1875-1890

2022

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RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication

Antimicrobial Agents and Chemotherapy, 2007-09, Vol.51 (9), p.3346-3353

2007

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Detection of Smallpox Virus DNA by LightCycler PCR

Journal of Clinical Microbiology, 2002-06, Vol.40 (6), p.1985-1988

2002

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Quantitative Real-Time Polymerase Chain Reaction for Evaluating DNAemia due to Cytomegalovirus, Epstein-Barr Virus, and BK Virus in Solid-Organ Transplant Recipients

Clinical infectious diseases, 2007-10, Vol.45 (8), p.1056-1061

2007

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Detection of Herpes Simplex Virus DNA in Genital and Dermal Specimens by LightCycler PCR after Extraction using the IsoQuick, MagNA Pure, and BioRobot 9604 Methods

Journal of Clinical Microbiology, 2001-06, Vol.39 (6), p.2233-2236

2001

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Acting professionally and impartially

Lab animal, 2020-07, Vol.49 (7), p.185-185

2020

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A Rheumatoid Nodule at the Sternoclavicular Joint: An uncommon presentation of a common problem

Marshall journal of medicine, 2022-10, Vol.8 (4)

2022

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Calling on a million minds for community annotation in WikiProteins

Genome biology, 2008-05, Vol.9 (5), p.R89-R89, Article R89

2008

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments

Pelvic congestion syndrome: Early clinical results after transcatheter ovarian vein embolization

Genomics and the search for novel biomarkers in toxicology

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells

Abstract LB-068: Development of a screening cascade to identify selective small molecule inhibitors of DNMT1

Abstract B05: Discovery, validation and targeting of novel synthetic lethal interactions in academic drug discovery

Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Abstract 2994: Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents

Abstract B98: Development and evaluation of selective, reversible LSD1 inhibitors from fragment startpoints

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h

Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication

Detection of Smallpox Virus DNA by LightCycler PCR

Quantitative Real-Time Polymerase Chain Reaction for Evaluating DNAemia due to Cytomegalovirus, Epstein-Barr Virus, and BK Virus in Solid-Organ Transplant Recipients

Detection of Herpes Simplex Virus DNA in Genital and Dermal Specimens by LightCycler PCR after Extraction using the IsoQuick, MagNA Pure, and BioRobot 9604 Methods

Acting professionally and impartially

A Rheumatoid Nodule at the Sternoclavicular Joint: An uncommon presentation of a common problem

Calling on a million minds for community annotation in WikiProteins

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