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Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat

Regulatory toxicology and pharmacology, 2022-06, Vol.131, p.105154-105154, Article 105154

2022

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Isoflucypram: A new fungicide with no thyroid related endocrine disrupting properties and an overall favorable mammalian safety profile

Toxicology letters, 2021-09, Vol.350, p.S246-S246

Tinwell, H.

2021

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Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test

Toxicology and applied pharmacology, 2021-12, Vol.433, p.115781, Article 115781

2021

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Evaluating H295R steroidogenesis assay data for robust interpretation

Regulatory toxicology and pharmacology, 2023-09, Vol.143, p.105461-105461, Article 105461

2023

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Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation

Regulatory toxicology and pharmacology, 2014-12, Vol.70 (3), p.648-658

2014

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Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines

Current research in toxicology, 2022-01, Vol.3, p.100086, Article 100086

2022

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P03-03 Quantitative in vitro to in vivo extrapolation (QIVIVE) for liver-induced thyroid toxicity risk assessment

Toxicology letters, 2024-09, Vol.399, p.S123-S124

2024

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Molecular neural crest cell markers enable discrimination of organophosphates in the murine cardiac embryonic stem cell test

Toxicology reports, 2021-01, Vol.8, p.1513-1520

2021

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Uterotrophic Activity of Bisphenol A in the Immature Rat

Environmental health perspectives, 1998-11, Vol.106 (11), p.719-720

1998

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P01-29 Assessment of in vitro approaches to identify succinate dehydrogenase inhibitors

Toxicology letters, 2024-09, Vol.399, p.S83-S83

2024

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P10-09 The importance of weight of evidence for assessment of non-endocrine active substances: a case study for Diflufenican

Toxicology letters, 2024-09, Vol.399, p.S189-S189

2024

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In vitro skin sensitization test methods: Applicability to plant protection products

Toxicology letters, 2021-09, Vol.350, p.S88-S88

2021

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Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via Uridine 5'-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation

Toxicology letters, 2021-09, Vol.350, p.S226-S226

2021

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P19-26 Moving towards a framework for in vitro risk assessment and determination of human relevance of rodent liver-mediated thyroid toxicity

Toxicology letters, 2024-09, Vol.399, p.S263-S264

2024

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P02-30 Generation and evaluation of a historical control database for the creation of assay acceptance criteria for a comparative in vitro hepatic enzyme assay

Toxicology letters, 2024-09, Vol.399, p.S116-S116

2024

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A microfluidic thyroid-liver platform to evaluate species-specific dysregulations of the thyroid hormone axis

Toxicology letters, 2021-09, Vol.350, p.S116-S117

2021

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Transcriptomic and morphological study of the influence of all-trans retinoic acid’s duration exposure on the zebrafish developmental mechanisms

Toxicology letters, 2021-09, Vol.350, p.S144-S144

2021

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A microfluidic two-organ chip to investigate species specific differences of thyroid-liver crosstalk in human and rats

Toxicology letters, 2021-09, Vol.350, p.S45-S45

2021

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Estradiol-Type Activity of Coumestrol in Mature and Immature Ovariectomized Rat Uterotrophic Assays

Environmental health perspectives, 2000-07, Vol.108 (7), p.631-634

2000

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The Effects of Atrazine on the Sexual Maturation of Female Rats

Regulatory toxicology and pharmacology, 2002-06, Vol.35 (3), p.468-473

2002

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Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects

Journal of applied toxicology, 1999-01, Vol.19 (1), p.39-45

1999

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Uterotrophic Activity of Bisphenol A in the Immature Mouse

Regulatory toxicology and pharmacology, 2000-08, Vol.32 (1), p.118-126

2000

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Sensitivity of the Immature Rat Uterotrophic Assay to Mixtures of Estrogens

Environmental health perspectives, 2004-04, Vol.112 (5), p.575-582

2004

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Induction of Hyperplasia and Increased DNA Content in the Uterus of Immature Rats Exposed to Coumestrol

Environmental health perspectives, 1999-10, Vol.107 (10), p.819-822

1999

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Phenotypic Anchoring of Gene Expression Changes during Estrogen-Induced Uterine Growth

Environmental health perspectives, 2004-11, Vol.112 (16), p.1589-1606

2004

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Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat

Isoflucypram: A new fungicide with no thyroid related endocrine disrupting properties and an overall favorable mammalian safety profile

Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test

Evaluating H295R steroidogenesis assay data for robust interpretation

Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation

Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines

P03-03 Quantitative in vitro to in vivo extrapolation (QIVIVE) for liver-induced thyroid toxicity risk assessment

Molecular neural crest cell markers enable discrimination of organophosphates in the murine cardiac embryonic stem cell test

Uterotrophic Activity of Bisphenol A in the Immature Rat

P01-29 Assessment of in vitro approaches to identify succinate dehydrogenase inhibitors

P10-09 The importance of weight of evidence for assessment of non-endocrine active substances: a case study for Diflufenican

In vitro skin sensitization test methods: Applicability to plant protection products

Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via Uridine 5'-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation

P19-26 Moving towards a framework for in vitro risk assessment and determination of human relevance of rodent liver-mediated thyroid toxicity

P02-30 Generation and evaluation of a historical control database for the creation of assay acceptance criteria for a comparative in vitro hepatic enzyme assay

A microfluidic thyroid-liver platform to evaluate species-specific dysregulations of the thyroid hormone axis

Transcriptomic and morphological study of the influence of all-trans retinoic acid’s duration exposure on the zebrafish developmental mechanisms

A microfluidic two-organ chip to investigate species specific differences of thyroid-liver crosstalk in human and rats

Estradiol-Type Activity of Coumestrol in Mature and Immature Ovariectomized Rat Uterotrophic Assays

The Effects of Atrazine on the Sexual Maturation of Female Rats

Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects

Uterotrophic Activity of Bisphenol A in the Immature Mouse

Sensitivity of the Immature Rat Uterotrophic Assay to Mixtures of Estrogens

Induction of Hyperplasia and Increased DNA Content in the Uterus of Immature Rats Exposed to Coumestrol

Phenotypic Anchoring of Gene Expression Changes during Estrogen-Induced Uterine Growth

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