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N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (1), p.312-317

2013

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New insights into the expanding complexity of the tumor suppressor ASPP2

Cell cycle (Georgetown, Tex.), 2009-09, Vol.8 (18), p.2871-2876

2009

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The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin

Cell cycle (Georgetown, Tex.), 2009-08, Vol.8 (16), p.2621-2630

2009

Volltextzugriff (PDF)

ASPP2κ Is Expressed In Human Colorectal Carcinoma And Promotes Chemotherapy Resistance And Tumorigenesis

Frontiers in molecular biosciences, 2021-11, Vol.8, p.727203-727203

2021

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Dasatinib overrides the differentiation blockage in a patient with mutant- KIT D816V positive CBFβ-MYH11 leukemia

Oncotarget, 2018-02, Vol.9 (14), p.11876-11882

2018

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A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

Anticancer research, 2019-01, Vol.39 (1), p.245-252

2019

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Alternative splicing of Apoptosis Stimulating Protein of TP53-2

BMC cancer, 2022-07, Vol.22 (1)

2022

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Abstract 2238: Role of phosphoinositide-dependent protein kinase-1 (PDK1) in leukemogenesis of acute leukemia

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2238-2238

2012

Volltextzugriff (PDF)

Abstract 4658: Delta9-Tetrahydrocannabinol induces apoptosis via Cannabinol Receptor 1 and modulates methylation of oncogenes and tumorsuppressors in blasts derived from patients with acute lympoblastic or myeloid leukemia

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.4658-4658

2012

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Abstract 2535: Inhibition of oncogenic ASPP2kappa(k), a dominant-negative isoform of the tumorsuppressor ASPP2, results in reactivation of p53 in glioblastoma

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2535-2535

2023

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ASPP2 Attenuation Is an Early Step in Leukemogenesis Facilitating Acquisition of Mutations

Blood, 2014-12, Vol.124 (21), p.2221-2221

2014

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Heatshockprotein-60/90 Are Overexpressed in Leukemia Stem Cells and Stabilize Oncogene Signaling

Blood, 2012-11, Vol.120 (21), p.2472-2472

2012

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Abstract 2496: Epothilones synergistically induce CRC cell death in combination with standard chemotherapy in part through a p53-dependent pathway

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2496-2496

2010

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Insights Into the Role of ASPP2 (Apoptosis Stimulating Protein of p53-2) in Lymphomagenesis

Blood, 2009-11, Vol.114 (22), p.1967-1967

2009

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FLT3 and KIT Isoforms Activate PI3K/AKT Signaling Which Is Potently Blocked by the Novel Dual PI3K/Mtor Inhibitors NVP-BEZ235 and NVP-BGT226

Blood, 2009-11, Vol.114 (22), p.1740-1740

2009

Volltextzugriff (PDF)

Gain-of-Function KIT Mutations Sensitize the Mutant Isoform to the Type I Tyrosine Kinase Inhibitor Crenolanib: A Rationale for the Therapeutic Use in Systemic Mastocytosis (SM) and Core Binding Factor Leukemias (CBFL)

Blood, 2014-12, Vol.124 (21), p.2230-2230

2014

Volltextzugriff (PDF)

Induction Of Apoptosis By The Dual PI3K/Mtor Inhibitor NVP-BEZ235 Is Impaired By a Profound G1/G0 Arrest In Acute Leukemia Which Can Be Overcome By Combination Approaches

Blood, 2013-11, Vol.122 (21), p.3856-3856

2013

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Heatshockproteins-60 and 90 Are Overexpressed In Leukemia Stem Cells and Stabilize Oncogene Signaling

Blood, 2013-11, Vol.122 (21), p.3952-3952

2013

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Identification Of C-Terminal Truncated Splice Variants Of The Apoptosis-Stimulating Protein Of p53-2 (ASPP2) In Acute Leukemia Lacking The p53-Binding Site

Blood, 2013-11, Vol.122 (21), p.1270-1270

2013

Volltextzugriff (PDF)

Identification of Three Tyrosine Phosphorylation Sites in the p53 Binding Domain of Apoptosis-Stimulating p53 Protein 2 (ASPP2) That Are Differentially Phosphorylated in Response to Chemotherapy in Patient Derived AML Blasts

Blood, 2011-11, Vol.118 (21), p.1396-1396

2011

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Abstract LB-49: Identification of C-terminal truncated splice variants of the apoptosis-stimulating protein of p53-2 (ASPP2) in acute leukemia

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.LB-49-LB-49

2013

Volltextzugriff (PDF)

Methylation Of The 5'UTR Of Apoptosis Stimulating Protein Of p53-2 (ASPP2) Impairs Gene Expression and Associates With Aggressive Disease and Therapy Failure In Acute Leukemia

Blood, 2013-11, Vol.122 (21), p.3770-3770

2013

Volltextzugriff (PDF)

Attenuation of Apoptosis-Stimulating Protein of p53 2 (ASPP2 or TP53BP2) Associates with High Risk Disease and Therapy Failure in Acute Leukemia

Blood, 2012-11, Vol.120 (21), p.1416-1416

2012

Volltextzugriff (PDF)

Efficacy Analysis of the Novel Dual PI3K-MTORC1/2 Inhibitors NVP-BGT226 and NVP-BEZ235 in Acute Leukemia

Blood, 2012-11, Vol.120 (21), p.2474-2474

2012

Volltextzugriff (PDF)

ASPP2 Expression In Acute Leukemia Modulates Response to Therapy

Blood, 2010-11, Vol.116 (21), p.3143-3143

2010

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N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

New insights into the expanding complexity of the tumor suppressor ASPP2

The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin

ASPP2κ Is Expressed In Human Colorectal Carcinoma And Promotes Chemotherapy Resistance And Tumorigenesis

Dasatinib overrides the differentiation blockage in a patient with mutant- KIT D816V positive CBFβ-MYH11 leukemia

A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

Alternative splicing of Apoptosis Stimulating Protein of TP53-2

Abstract 2238: Role of phosphoinositide-dependent protein kinase-1 (PDK1) in leukemogenesis of acute leukemia

Abstract 4658: Delta9-Tetrahydrocannabinol induces apoptosis via Cannabinol Receptor 1 and modulates methylation of oncogenes and tumorsuppressors in blasts derived from patients with acute lympoblastic or myeloid leukemia

Abstract 2535: Inhibition of oncogenic ASPP2kappa(k), a dominant-negative isoform of the tumorsuppressor ASPP2, results in reactivation of p53 in glioblastoma

ASPP2 Attenuation Is an Early Step in Leukemogenesis Facilitating Acquisition of Mutations

Heatshockprotein-60/90 Are Overexpressed in Leukemia Stem Cells and Stabilize Oncogene Signaling

Abstract 2496: Epothilones synergistically induce CRC cell death in combination with standard chemotherapy in part through a p53-dependent pathway

Insights Into the Role of ASPP2 (Apoptosis Stimulating Protein of p53-2) in Lymphomagenesis

FLT3 and KIT Isoforms Activate PI3K/AKT Signaling Which Is Potently Blocked by the Novel Dual PI3K/Mtor Inhibitors NVP-BEZ235 and NVP-BGT226

Gain-of-Function KIT Mutations Sensitize the Mutant Isoform to the Type I Tyrosine Kinase Inhibitor Crenolanib: A Rationale for the Therapeutic Use in Systemic Mastocytosis (SM) and Core Binding Factor Leukemias (CBFL)

Induction Of Apoptosis By The Dual PI3K/Mtor Inhibitor NVP-BEZ235 Is Impaired By a Profound G1/G0 Arrest In Acute Leukemia Which Can Be Overcome By Combination Approaches

Heatshockproteins-60 and 90 Are Overexpressed In Leukemia Stem Cells and Stabilize Oncogene Signaling

Identification Of C-Terminal Truncated Splice Variants Of The Apoptosis-Stimulating Protein Of p53-2 (ASPP2) In Acute Leukemia Lacking The p53-Binding Site

Identification of Three Tyrosine Phosphorylation Sites in the p53 Binding Domain of Apoptosis-Stimulating p53 Protein 2 (ASPP2) That Are Differentially Phosphorylated in Response to Chemotherapy in Patient Derived AML Blasts

Abstract LB-49: Identification of C-terminal truncated splice variants of the apoptosis-stimulating protein of p53-2 (ASPP2) in acute leukemia

Methylation Of The 5'UTR Of Apoptosis Stimulating Protein Of p53-2 (ASPP2) Impairs Gene Expression and Associates With Aggressive Disease and Therapy Failure In Acute Leukemia

Attenuation of Apoptosis-Stimulating Protein of p53 2 (ASPP2 or TP53BP2) Associates with High Risk Disease and Therapy Failure in Acute Leukemia

Efficacy Analysis of the Novel Dual PI3K-MTORC1/2 Inhibitors NVP-BGT226 and NVP-BEZ235 in Acute Leukemia

ASPP2 Expression In Acute Leukemia Modulates Response to Therapy

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