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“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

Pharmacology & therapeutics (Oxford), 2022-08, Vol.236, p.108234-108234, Article 108234

Sakai, Toshiyuki

2022

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HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

ACS applied materials & interfaces, 2024-09, Vol.16 (38), p.50474-50483

2024

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EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

AL ULUM: JURNAL SAINS DAN TEKNOLOGI, 2023-08, Vol.9 (2), p.84

2023

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Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Accounts of chemical research, 2012-05, Vol.45 (5), p.756-766

2012

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Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase

Chemistry : a European journal, 2019-04, Vol.25 (21), p.5337-5371

2019

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Improved chemical synthesis, identification and evaluation of prospective centrally active oxime antidotes for the treatment of nerve agent exposure

Tetrahedron, 2023-08, Vol.144 (7)

2023

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A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

Chinese journal of natural medicines, 2024-02, Vol.22 (2), p.112-126

2024

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Improved chemical synthesis, identification and evaluation of prospective centrally active oxime antidotes for the treatment of nerve agent exposure

Tetrahedron, 2023-09, Vol.144 (C), p.133598, Article 133598

2023

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A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators

Current organic chemistry, 2018-01, Vol.22 (16), p.1619-1648

2018

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Penetrating the Blood-Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH 2 (Fe)

ACS applied materials & interfaces, 2023-03, Vol.15 (10), p.12631-12642

2023

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Diagnostics and treatment of nerve agent poisoning—current status and future developments

Annals of the New York Academy of Sciences, 2020-11, Vol.1479 (1), p.13-28

2020

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Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

Inorganic chemistry, 2023-04, Vol.62 (13), p.5049-5053

2023

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Nature (London), 2011-01, Vol.469 (7328), p.102-106

2011

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Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

Chemistry : a European journal, 2022-07, Vol.28 (40), p.e202200678-n/a

2022

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New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase

Bioorganic & medicinal chemistry, 2007-12, Vol.15 (24), p.7704-7710

2007

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Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (E)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5514-5518

2007

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Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2914-2917

2005

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In silico Study of Potential Non-oxime Reactivator for Sarin-inhibited Human Acetylcholinesterase

Pertanika Journal of Science and Technology, 2021-07, Vol.29 (3)

2021

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Nanoparticle-Delivered 2‑PAM for Rat Brain Protection against Paraoxon Central Toxicity

ACS applied materials & interfaces, 2017-05, Vol.9 (20), p.16922-16932

2017

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Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (20), p.5514-5519

2016

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Zn(II)/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies

Journal of inorganic biochemistry, 2014-05, Vol.134, p.12-19

2014

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A fieldable, high-throughput, cost-efficient high performance liquid chromatography-ultraviolet absorption detection (HPLC-UV) method for the quantitation of bispyridinium quaternary aldoxime cholinesterase reactivators in blood

Acta chromatographica, 2021-06, Vol.33 (2), p.134-144

2021

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Holy Moly: Hermes’ Anticholinesterase Antidote

Anesthesiology (Philadelphia), 2014-08, Vol.121 (2), p.371-371

2014

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Comparison of 3-carbethoxy-4-phenyl-but-3-en-2-one and methylene quinuclidinone as a ligand to reactivate mutant p53: molecular docking study in three types of crystal structure mutant p53: 2BIM, 2JIY, and 2J21

Research journal of pharmacy and technology, 2021-06, Vol.14 (6), p.3358-3364

2021

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Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma

Cellular physiology and biochemistry, 2019-01, Vol.51 (6), p.2536-2546

2019

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“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase

Improved chemical synthesis, identification and evaluation of prospective centrally active oxime antidotes for the treatment of nerve agent exposure

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

Improved chemical synthesis, identification and evaluation of prospective centrally active oxime antidotes for the treatment of nerve agent exposure

A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators

Penetrating the Blood-Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH 2 (Fe)

Diagnostics and treatment of nerve agent poisoning—current status and future developments

Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase

Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (E)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents

In silico Study of Potential Non-oxime Reactivator for Sarin-inhibited Human Acetylcholinesterase

Nanoparticle-Delivered 2‑PAM for Rat Brain Protection against Paraoxon Central Toxicity

Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

Zn(II)/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies

A fieldable, high-throughput, cost-efficient high performance liquid chromatography-ultraviolet absorption detection (HPLC-UV) method for the quantitation of bispyridinium quaternary aldoxime cholinesterase reactivators in blood

Holy Moly: Hermes’ Anticholinesterase Antidote

Comparison of 3-carbethoxy-4-phenyl-but-3-en-2-one and methylene quinuclidinone as a ligand to reactivate mutant p53: molecular docking study in three types of crystal structure mutant p53: 2BIM, 2JIY, and 2J21

Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma

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