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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

PloS one, 2012-04, Vol.7 (4), p.e34822

2012

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Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3555-3560

1998

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Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2677-2686

2000

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Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4644-4648

1996

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5886-5887

1991

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The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (9), p.3764-3768

1995

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The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Journal of the American Chemical Society, 1991-11, Vol.113 (23), p.9009-9009

1991

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Catalysis by Cytochrome P-450 of an Oxidative Reaction in Xenobiotic Aldehyde Metabolism: Deformylation with Olefin Formation

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (20), p.8963-8966

1991

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A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

Journal of organic chemistry, 1984-04, Vol.49 (7), p.1286-1288

1984

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In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240

2003

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Peroxidative reactions of diversozymes 1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Peroxidative reactions of diversozymes1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Reductive β-Scission of the Hydroperoxides of Fatty Acids and Xenobiotics: Role of Alcohol-Inducible Cytochrome P-450

Proceedings of the National Academy of Sciences - PNAS, 1990-07, Vol.87 (14), p.5499-5503

1990

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Evidence for a Role of a Perferryl-Oxygen Complex, FeO 3+ , in the N -Oxygenation of Amines by Cytochrome P450 Enzymes

Molecular pharmacology, 1997-01, Vol.51 (1), p.147-151

1997

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Hydrocarbon Formation in the Reductive Cleavage of Hydroperoxides by Cytochrome P-450

Proceedings of the National Academy of Sciences - PNAS, 1987-03, Vol.84 (5), p.1172-1176

1987

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Drug Metabolism: Significance and Challenges

Nuclear Receptors in Drug Metabolism, 2008, p.1-41

2008

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Synthesis of β-3H-mitotane for use in a rapid assay for mitotane metabolism

Journal of labelled compounds & radiopharmaceuticals, 1995-02, Vol.36 (2), p.121-127

1995

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Dehydroquinase catalyzed dehydration. II. Identification of the reactive conformation of the substrate responsible for syn elimination

Journal of the American Chemical Society, 1975-10, Vol.97 (20), p.5914-5915

1975

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Radical intermediates in the catalytic cycles of cytochrome P-450

Basic life sciences, 1988, Vol.49, p.501

1988

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Catalysis by Cytochrome P-450 of an Oxidative Reaction in Xenobiotic Aldehyde Metabolism: Deformylation with Olefin Formation

A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

Peroxidative reactions of diversozymes 1

Peroxidative reactions of diversozymes1

Reductive β-Scission of the Hydroperoxides of Fatty Acids and Xenobiotics: Role of Alcohol-Inducible Cytochrome P-450

Evidence for a Role of a Perferryl-Oxygen Complex, FeO 3+ , in the N -Oxygenation of Amines by Cytochrome P450 Enzymes

Hydrocarbon Formation in the Reductive Cleavage of Hydroperoxides by Cytochrome P-450

Drug Metabolism: Significance and Challenges

Synthesis of β-3H-mitotane for use in a rapid assay for mitotane metabolism

Dehydroquinase catalyzed dehydration. II. Identification of the reactive conformation of the substrate responsible for syn elimination

Radical intermediates in the catalytic cycles of cytochrome P-450

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