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The Natural Polyamine Spermine Functions Directly as a Free Radical Scavenger

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (19), p.11140-11145

1998

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The Role of Polyamine Catabolism in Polyamine Analogue-Induced Programmed Cell Death

Proceedings of the National Academy of Sciences - PNAS, 1997-10, Vol.94 (21), p.11557-11562

1997

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v-Ha-ras Oncogene Insertion: A Model for Tumor Progression of Human Small Cell Lung Cancer

Proceedings of the National Academy of Sciences - PNAS, 1988-09, Vol.85 (17), p.6523-6527

1988

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The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes

Clinical cancer research, 1998-06, Vol.4 (6), p.1557-1561

1998

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Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue

Clinical cancer research, 1998-08, Vol.4 (8), p.2003-2008

1998

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Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene

The Journal of biological chemistry, 1999-07, Vol.274 (31), p.22095-22101

1999

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Comparison of the effects of treatment with the polyamine analogue N1,N8 bis(ethyl)spermidine (BESpd) or difluoromethylornithine (DFMO) on the topoisomerase II mediated formation of 4'-(9-acridinylamino) methanesulfon-M-anisidide (m-AMSA) induced cleavable complex in the human lung carcinoma line NCI H157

Biochemical and biophysical research communications, 1987-11, Vol.149 (1), p.194-202

1987

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Activity of tunicamycin against Trypanosoma brucei in vitro and in vivo

Antimicrobial Agents and Chemotherapy, 1982-12, Vol.22 (6), p.1008-1011

1982

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Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine

Cancer research (Chicago, Ill.), 1993-05, Vol.53 (9), p.2071-2075

1993

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Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

Biochemical journal, 2001-04, Vol.355 (Pt 1), p.45-49

2001

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Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells

Clinical cancer research, 2000-01, Vol.6 (1), p.17

2000

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Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues

Cancer research (Chicago, Ill.), 1994-08, Vol.54 (15), p.3955-3958

1994

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High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma

Biochemical journal, 1990-09, Vol.270 (3), p.615-620

1990

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Activity of 2-acetylpyridine thiosemicarbazones against Trypanosoma rhodesiense in vitro

Antimicrobial Agents and Chemotherapy, 1980-08, Vol.18 (2), p.317-322

1980

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The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine N1-acetyltransferase gene transcription

The Journal of biological chemistry, 1998-12, Vol.273 (51), p.34623

1998

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The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1, N11-bis(ethyl)norspermine

Clinical cancer research, 1999-07, Vol.5 (7), p.1638-1641

1999

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Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells

Biochemical journal, 1996-01, Vol.313 ( Pt 2) (Pt 2), p.691-696

1996

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Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1

Cancer chemotherapy and pharmacology, 1995, Vol.36 (1), p.69-74

1995

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Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels

Journal of cellular physiology, 1998-03, Vol.174 (3), p.380-386

1998

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Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor

Biochemical journal, 2001-10, Vol.359 (2), p.387-392

2001

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Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N super(1)-acetyltransferase (SSAT) gene

Biochemical journal, 2001-04, Vol.355 (1), p.45-49

2001

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RGFGIGS Is an Amino Acid Sequence Required for Acetyl Coenzyme A Binding and Activity of Human Spermidine/Spermine N1Acetyltransferase

The Journal of biological chemistry, 1996-08, Vol.271 (31), p.18920-18924

1996

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Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine

Journal of cellular physiology, 1995-10, Vol.165 (1), p.71-76

1995

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Cloning and Characterization of Human Polyamine-modulated Factor-1, a Transcriptional Cofactor That Regulates the Transcription of the Spermidine/Spermine N super(1)-Acetyltransferase Gene

The Journal of biological chemistry, 1999-07, Vol.274 (31), p.22095-22101

1999

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Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine- N1-acetyltransferase

Bioorganic & medicinal chemistry, 1996-06, Vol.4 (6), p.825-836

1996

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The Natural Polyamine Spermine Functions Directly as a Free Radical Scavenger

The Role of Polyamine Catabolism in Polyamine Analogue-Induced Programmed Cell Death

v-Ha-ras Oncogene Insertion: A Model for Tumor Progression of Human Small Cell Lung Cancer

The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes

Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue

Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene

Activity of tunicamycin against Trypanosoma brucei in vitro and in vivo

Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells

Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues

High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma

Activity of 2-acetylpyridine thiosemicarbazones against Trypanosoma rhodesiense in vitro

The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine N1-acetyltransferase gene transcription

The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1, N11-bis(ethyl)norspermine

Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells

Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1

Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels

Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N super(1)-acetyltransferase (SSAT) gene

RGFGIGS Is an Amino Acid Sequence Required for Acetyl Coenzyme A Binding and Activity of Human Spermidine/Spermine N1Acetyltransferase

Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine

Cloning and Characterization of Human Polyamine-modulated Factor-1, a Transcriptional Cofactor That Regulates the Transcription of the Spermidine/Spermine N super(1)-Acetyltransferase Gene

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine- N1-acetyltransferase

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